Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection

Bacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear. Here, we identified that an ASC-dependent inflammasome activation played opposite roles in host defense against Francisella novi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu Guo, Rudi Mao, Qingqing Xie, Xiaojie Cheng, Tao Xu, Xiaoyuan Wang, Yan Du, Xiaopeng Qi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Francisella novicida XWK4 AIM2 NLRP3 ASC Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/25f9f56fa42e4f47a6087e827c382998
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:25f9f56fa42e4f47a6087e827c382998
record_format	dspace
spelling	oai:doaj.org-article:25f9f56fa42e4f47a6087e827c3829982021-11-18T09:49:43ZFrancisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection2296-634X10.3389/fcell.2021.743335https://doaj.org/article/25f9f56fa42e4f47a6087e827c3829982021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.743335/fullhttps://doaj.org/toc/2296-634XBacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear. Here, we identified that an ASC-dependent inflammasome activation played opposite roles in host defense against Francisella novicida wild-type (WT) U112 and mutant strain XWK4. Comparing with U112, XWK4 infection induced robust cytokine production, ASC-dependent inflammasome activation, and pyroptosis. Both AIM2 and NLRP3 were involved and played independent roles in XWK4-induced inflammasome activation. Type II interferon was partially required for XWK4-triggered inflammasome activation, which was different from type I interferon dependency in U112-induced inflammasome activation. Distinct from F. novicida U112 and Acinetobacter baumannii infection, Asc–/– mice were more resistant than WT mice response to XWK4 infection by limiting bacterial burden in vivo. The excessive inflammasome activation triggered by XWK4 infection caused dramatical cell death and pathological damage. Our study offers novel insights into mechanisms of inflammasome activation in host defense and provides potential therapeutic approach against bacterial infections and inflammatory diseases.Yu GuoYu GuoRudi MaoQingqing XieXiaojie ChengTao XuXiaoyuan WangYan DuYan DuXiaopeng QiXiaopeng QiXiaopeng QiFrontiers Media S.A.articleFrancisella novicidaXWK4AIM2NLRP3ASCBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Francisella novicida XWK4 AIM2 NLRP3 ASC Biology (General) QH301-705.5
spellingShingle	Francisella novicida XWK4 AIM2 NLRP3 ASC Biology (General) QH301-705.5 Yu Guo Yu Guo Rudi Mao Qingqing Xie Xiaojie Cheng Tao Xu Xiaoyuan Wang Yan Du Yan Du Xiaopeng Qi Xiaopeng Qi Xiaopeng Qi Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
description	Bacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear. Here, we identified that an ASC-dependent inflammasome activation played opposite roles in host defense against Francisella novicida wild-type (WT) U112 and mutant strain XWK4. Comparing with U112, XWK4 infection induced robust cytokine production, ASC-dependent inflammasome activation, and pyroptosis. Both AIM2 and NLRP3 were involved and played independent roles in XWK4-induced inflammasome activation. Type II interferon was partially required for XWK4-triggered inflammasome activation, which was different from type I interferon dependency in U112-induced inflammasome activation. Distinct from F. novicida U112 and Acinetobacter baumannii infection, Asc–/– mice were more resistant than WT mice response to XWK4 infection by limiting bacterial burden in vivo. The excessive inflammasome activation triggered by XWK4 infection caused dramatical cell death and pathological damage. Our study offers novel insights into mechanisms of inflammasome activation in host defense and provides potential therapeutic approach against bacterial infections and inflammatory diseases.
format	article
author	Yu Guo Yu Guo Rudi Mao Qingqing Xie Xiaojie Cheng Tao Xu Xiaoyuan Wang Yan Du Yan Du Xiaopeng Qi Xiaopeng Qi Xiaopeng Qi
author_facet	Yu Guo Yu Guo Rudi Mao Qingqing Xie Xiaojie Cheng Tao Xu Xiaoyuan Wang Yan Du Yan Du Xiaopeng Qi Xiaopeng Qi Xiaopeng Qi
author_sort	Yu Guo
title	Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
title_short	Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
title_full	Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
title_fullStr	Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
title_full_unstemmed	Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
title_sort	francisella novicida mutant xwk4 triggers robust inflammasome activation favoring infection
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/25f9f56fa42e4f47a6087e827c382998
work_keys_str_mv	AT yuguo francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT yuguo francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT rudimao francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT qingqingxie francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT xiaojiecheng francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT taoxu francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT xiaoyuanwang francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT yandu francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT yandu francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT xiaopengqi francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT xiaopengqi francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection AT xiaopengqi francisellanovicidamutantxwk4triggersrobustinflammasomeactivationfavoringinfection
_version_	1718420833021460480

Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection

Ejemplares similares