Astragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology

Xin-Yu Li,1,2 Liang Shen,1,2 Hong-Fang Ji1,21Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People’s Republic of China; 2Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Zibo Key Laboratory of New Drug Development of Neu...

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Autores principales:	Li XY, Shen L, Ji HF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/26019a51418c4e328c4d45ca068645b1
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spelling	oai:doaj.org-article:26019a51418c4e328c4d45ca068645b12021-12-02T05:57:09ZAstragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology1178-7007https://doaj.org/article/26019a51418c4e328c4d45ca068645b12019-05-01T00:00:00Zhttps://www.dovepress.com/astragalus-alters-gut-microbiota-composition-in-type-2-diabetes-mice-c-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xin-Yu Li,1,2 Liang Shen,1,2 Hong-Fang Ji1,21Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People’s Republic of China; 2Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Zibo Key Laboratory of New Drug Development of Neurodegenerative Diseases, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People’s Republic of ChinaBackground: Astragalus possesses therapeutic effects for type 2 diabetes (T2D), while its action mechanisms remain to be elucidated. In view of the pathogenic associations between gut microbiota and T2D, we explored the effect of astragalus on gut-microbiota composition of T2D mice.Materials and methods: Modulation effects of astragalus on gut microbiota of T2D-model mice were assessed by 16S rRNA gene sequencing.Results: Inhibited blood-glucose and body-weight levels of T2D mice by astragalus were accompanied by gut microbiota–composition alteration. Astragalus administration significantly increased gut-microbiota richness and diversity in T2D mice and significantly altered the abundance of several bacterial taxa, inducing increased abundance of Lactobacillus and Bifidobacterium. PICRUSt software revealed the relationship between astragalus and T2D.Conclusion: Due to previously reported decreased gut-microbiota richness and diversity and reduced abundance of key species of Lactobacillus and Bifidobacterium, more studies are encouraged to explore the contribution of gut-microbiota alteration by astragalus to its anti-T2D effect.Keywords: astragalus, type 2 diabetes, gut microbiota, alteration, 16S rRNA gene sequencingLi XYShen LJi HFDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 771-778 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Li XY Shen L Ji HF Astragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology
description	Xin-Yu Li,1,2 Liang Shen,1,2 Hong-Fang Ji1,21Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People’s Republic of China; 2Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Zibo Key Laboratory of New Drug Development of Neurodegenerative Diseases, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People’s Republic of ChinaBackground: Astragalus possesses therapeutic effects for type 2 diabetes (T2D), while its action mechanisms remain to be elucidated. In view of the pathogenic associations between gut microbiota and T2D, we explored the effect of astragalus on gut-microbiota composition of T2D mice.Materials and methods: Modulation effects of astragalus on gut microbiota of T2D-model mice were assessed by 16S rRNA gene sequencing.Results: Inhibited blood-glucose and body-weight levels of T2D mice by astragalus were accompanied by gut microbiota–composition alteration. Astragalus administration significantly increased gut-microbiota richness and diversity in T2D mice and significantly altered the abundance of several bacterial taxa, inducing increased abundance of Lactobacillus and Bifidobacterium. PICRUSt software revealed the relationship between astragalus and T2D.Conclusion: Due to previously reported decreased gut-microbiota richness and diversity and reduced abundance of key species of Lactobacillus and Bifidobacterium, more studies are encouraged to explore the contribution of gut-microbiota alteration by astragalus to its anti-T2D effect.Keywords: astragalus, type 2 diabetes, gut microbiota, alteration, 16S rRNA gene sequencing
format	article
author	Li XY Shen L Ji HF
author_facet	Li XY Shen L Ji HF
author_sort	Li XY
title	Astragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology
title_short	Astragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology
title_full	Astragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology
title_fullStr	Astragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology
title_full_unstemmed	Astragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology
title_sort	astragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/26019a51418c4e328c4d45ca068645b1
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Astragalus alters gut-microbiota composition in type 2 diabetes mice: clues to its pharmacology

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