Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats

Neonatal immune responses are known to differ to those of an adult immune response. Here Dreschers and colleagues, compare macrophage populations derived from cord blood or adult peripheral blood and show a metabolic impairment of glycolysis in macrophages derived from cord blood which may impair re...

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Autores principales:	Stephan Dreschers, Kim Ohl, Michael Lehrke, Julia Möllmann, Bernd Denecke, Ivan Costa, Thomas Vogl, Dorothee Viemann, Johannes Roth, Thorsten Orlikowsky, Klaus Tenbrock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2601ea47e4694ca196e679dd24056f2c
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spelling	oai:doaj.org-article:2601ea47e4694ca196e679dd24056f2c2021-12-02T14:39:39ZImpaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats10.1038/s41467-019-09359-82041-1723https://doaj.org/article/2601ea47e4694ca196e679dd24056f2c2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09359-8https://doaj.org/toc/2041-1723Neonatal immune responses are known to differ to those of an adult immune response. Here Dreschers and colleagues, compare macrophage populations derived from cord blood or adult peripheral blood and show a metabolic impairment of glycolysis in macrophages derived from cord blood which may impair response to infective scenarios such as sepsis.Stephan DreschersKim OhlMichael LehrkeJulia MöllmannBernd DeneckeIvan CostaThomas VoglDorothee ViemannJohannes RothThorsten OrlikowskyKlaus TenbrockNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephan Dreschers Kim Ohl Michael Lehrke Julia Möllmann Bernd Denecke Ivan Costa Thomas Vogl Dorothee Viemann Johannes Roth Thorsten Orlikowsky Klaus Tenbrock Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
description	Neonatal immune responses are known to differ to those of an adult immune response. Here Dreschers and colleagues, compare macrophage populations derived from cord blood or adult peripheral blood and show a metabolic impairment of glycolysis in macrophages derived from cord blood which may impair response to infective scenarios such as sepsis.
format	article
author	Stephan Dreschers Kim Ohl Michael Lehrke Julia Möllmann Bernd Denecke Ivan Costa Thomas Vogl Dorothee Viemann Johannes Roth Thorsten Orlikowsky Klaus Tenbrock
author_facet	Stephan Dreschers Kim Ohl Michael Lehrke Julia Möllmann Bernd Denecke Ivan Costa Thomas Vogl Dorothee Viemann Johannes Roth Thorsten Orlikowsky Klaus Tenbrock
author_sort	Stephan Dreschers
title	Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
title_short	Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
title_full	Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
title_fullStr	Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
title_full_unstemmed	Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
title_sort	impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2601ea47e4694ca196e679dd24056f2c
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Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats

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