Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

Stem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivota...

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Autores principales:	Jiawen Chen, Tianyu Sun, Yan You, Buling Wu, Xiaofang Wang, Jingyi Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	proteoglycan glycosaminoglyans mesenchymal stem cell stem cell homeostasis differentiation self-renewal Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2602ab20a0c5420391eaa23699658dac
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spelling	oai:doaj.org-article:2602ab20a0c5420391eaa23699658dac2021-12-01T15:18:37ZProteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration2296-634X10.3389/fcell.2021.760532https://doaj.org/article/2602ab20a0c5420391eaa23699658dac2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.760532/fullhttps://doaj.org/toc/2296-634XStem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivotal roles in facilitating signaling transduction and maintaining stem cell homeostasis. In this review, we outline distinct proteoglycans profiles and their functions in the regulation of stem cell homeostasis, as well as recent progress and prospects of utilizing proteoglycans/glycosaminoglycans as a novel glycomics carrier or bio-active molecules in bone regeneration.Jiawen ChenTianyu SunYan YouBuling WuBuling WuXiaofang WangJingyi WuFrontiers Media S.A.articleproteoglycanglycosaminoglyansmesenchymal stem cellstem cell homeostasisdifferentiationself-renewalBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	proteoglycan glycosaminoglyans mesenchymal stem cell stem cell homeostasis differentiation self-renewal Biology (General) QH301-705.5
spellingShingle	proteoglycan glycosaminoglyans mesenchymal stem cell stem cell homeostasis differentiation self-renewal Biology (General) QH301-705.5 Jiawen Chen Tianyu Sun Yan You Buling Wu Buling Wu Xiaofang Wang Jingyi Wu Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration
description	Stem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivotal roles in facilitating signaling transduction and maintaining stem cell homeostasis. In this review, we outline distinct proteoglycans profiles and their functions in the regulation of stem cell homeostasis, as well as recent progress and prospects of utilizing proteoglycans/glycosaminoglycans as a novel glycomics carrier or bio-active molecules in bone regeneration.
format	article
author	Jiawen Chen Tianyu Sun Yan You Buling Wu Buling Wu Xiaofang Wang Jingyi Wu
author_facet	Jiawen Chen Tianyu Sun Yan You Buling Wu Buling Wu Xiaofang Wang Jingyi Wu
author_sort	Jiawen Chen
title	Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration
title_short	Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration
title_full	Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration
title_fullStr	Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration
title_full_unstemmed	Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration
title_sort	proteoglycans and glycosaminoglycans in stem cell homeostasis and bone tissue regeneration
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2602ab20a0c5420391eaa23699658dac
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Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

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