Time-of-day-dependent enhancement of adult neurogenesis in the hippocampus.

<h4>Background</h4>Adult neurogenesis occurs in specific regions of the mammalian brain such as the dentate gyrus of the hippocampus. In the neurogenic region, neural progenitor cells continuously divide and give birth to new neurons. Although biological properties of neurons and glia in...

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Autores principales:	So-ichi Tamai, Kamon Sanada, Yoshitaka Fukada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/260480ce4c3a42269a2c7242e1a13349
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spelling	oai:doaj.org-article:260480ce4c3a42269a2c7242e1a133492021-11-25T06:18:21ZTime-of-day-dependent enhancement of adult neurogenesis in the hippocampus.1932-620310.1371/journal.pone.0003835https://doaj.org/article/260480ce4c3a42269a2c7242e1a133492008-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19048107/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Adult neurogenesis occurs in specific regions of the mammalian brain such as the dentate gyrus of the hippocampus. In the neurogenic region, neural progenitor cells continuously divide and give birth to new neurons. Although biological properties of neurons and glia in the hippocampus have been demonstrated to fluctuate depending on specific times of the day, it is unclear if neural progenitors and neurogenesis in the adult brain are temporally controlled within the day.<h4>Methodology/principal findings</h4>Here we demonstrate that in the dentate gyrus of the adult mouse hippocampus, the number of M-phase cells shows a day/night variation throughout the day, with a significant increase during the nighttime. The M-phase cell number is constant throughout the day in the subventricular zone of the forebrain, another site of adult neurogenesis, indicating the daily rhythm of progenitor mitosis is region-specific. Importantly, the nighttime enhancement of hippocampal progenitor mitosis is accompanied by a nighttime increase of newborn neurons.<h4>Conclusions/significance</h4>These results indicate that neurogenesis in the adult hippocampus occurs in a time-of-day-dependent fashion, which may dictate daily modifications of dentate gyrus physiology.So-ichi TamaiKamon SanadaYoshitaka FukadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 12, p e3835 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q So-ichi Tamai Kamon Sanada Yoshitaka Fukada Time-of-day-dependent enhancement of adult neurogenesis in the hippocampus.
description	<h4>Background</h4>Adult neurogenesis occurs in specific regions of the mammalian brain such as the dentate gyrus of the hippocampus. In the neurogenic region, neural progenitor cells continuously divide and give birth to new neurons. Although biological properties of neurons and glia in the hippocampus have been demonstrated to fluctuate depending on specific times of the day, it is unclear if neural progenitors and neurogenesis in the adult brain are temporally controlled within the day.<h4>Methodology/principal findings</h4>Here we demonstrate that in the dentate gyrus of the adult mouse hippocampus, the number of M-phase cells shows a day/night variation throughout the day, with a significant increase during the nighttime. The M-phase cell number is constant throughout the day in the subventricular zone of the forebrain, another site of adult neurogenesis, indicating the daily rhythm of progenitor mitosis is region-specific. Importantly, the nighttime enhancement of hippocampal progenitor mitosis is accompanied by a nighttime increase of newborn neurons.<h4>Conclusions/significance</h4>These results indicate that neurogenesis in the adult hippocampus occurs in a time-of-day-dependent fashion, which may dictate daily modifications of dentate gyrus physiology.
format	article
author	So-ichi Tamai Kamon Sanada Yoshitaka Fukada
author_facet	So-ichi Tamai Kamon Sanada Yoshitaka Fukada
author_sort	So-ichi Tamai
title	Time-of-day-dependent enhancement of adult neurogenesis in the hippocampus.
title_short	Time-of-day-dependent enhancement of adult neurogenesis in the hippocampus.
title_full	Time-of-day-dependent enhancement of adult neurogenesis in the hippocampus.
title_fullStr	Time-of-day-dependent enhancement of adult neurogenesis in the hippocampus.
title_full_unstemmed	Time-of-day-dependent enhancement of adult neurogenesis in the hippocampus.
title_sort	time-of-day-dependent enhancement of adult neurogenesis in the hippocampus.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/260480ce4c3a42269a2c7242e1a13349
work_keys_str_mv	AT soichitamai timeofdaydependentenhancementofadultneurogenesisinthehippocampus AT kamonsanada timeofdaydependentenhancementofadultneurogenesisinthehippocampus AT yoshitakafukada timeofdaydependentenhancementofadultneurogenesisinthehippocampus
_version_	1718413912512135168

Time-of-day-dependent enhancement of adult neurogenesis in the hippocampus.

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