The protective role of DOT1L in UV-induced melanomagenesis

The protective role of DOT1L in UV-induced melanomagenesis

The interaction of DOT1L with MLL oncogenic fusion proteins has been implicated in leukemogenesis. Here, the authors show a contrasting role for DOT1L in protecting UVR-induced melanomagenesis by facilitating DNA repair through interaction with XPC.

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Autores principales: Bo Zhu, Shuyang Chen, Hongshen Wang, Chengqian Yin, Changpeng Han, Cong Peng, Zhaoqian Liu, Lixin Wan, Xiaoyang Zhang, Jie Zhang, Christine G. Lian, Peilin Ma, Zhi-xiang Xu, Sharon Prince, Tao Wang, Xiumei Gao, Yujiang Shi, Dali Liu, Min Liu, Wenyi Wei, Zhi Wei, Jingxuan Pan, Yongjun Wang, Zhenyu Xuan, Jay Hess, Nicholas K. Hayward, Colin R. Goding, Xiang Chen, Jun Zhou, Rutao Cui
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2605881fd6234a65adf003e2d0a77077
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spelling oai:doaj.org-article:2605881fd6234a65adf003e2d0a770772021-12-02T14:40:43ZThe protective role of DOT1L in UV-induced melanomagenesis10.1038/s41467-017-02687-72041-1723https://doaj.org/article/2605881fd6234a65adf003e2d0a770772018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02687-7https://doaj.org/toc/2041-1723The interaction of DOT1L with MLL oncogenic fusion proteins has been implicated in leukemogenesis. Here, the authors show a contrasting role for DOT1L in protecting UVR-induced melanomagenesis by facilitating DNA repair through interaction with XPC.Bo ZhuShuyang ChenHongshen WangChengqian YinChangpeng HanCong PengZhaoqian LiuLixin WanXiaoyang ZhangJie ZhangChristine G. LianPeilin MaZhi-xiang XuSharon PrinceTao WangXiumei GaoYujiang ShiDali LiuMin LiuWenyi WeiZhi WeiJingxuan PanYongjun WangZhenyu XuanJay HessNicholas K. HaywardColin R. GodingXiang ChenJun ZhouRutao CuiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bo Zhu
Shuyang Chen
Hongshen Wang
Chengqian Yin
Changpeng Han
Cong Peng
Zhaoqian Liu
Lixin Wan
Xiaoyang Zhang
Jie Zhang
Christine G. Lian
Peilin Ma
Zhi-xiang Xu
Sharon Prince
Tao Wang
Xiumei Gao
Yujiang Shi
Dali Liu
Min Liu
Wenyi Wei
Zhi Wei
Jingxuan Pan
Yongjun Wang
Zhenyu Xuan
Jay Hess
Nicholas K. Hayward
Colin R. Goding
Xiang Chen
Jun Zhou
Rutao Cui
The protective role of DOT1L in UV-induced melanomagenesis
description The interaction of DOT1L with MLL oncogenic fusion proteins has been implicated in leukemogenesis. Here, the authors show a contrasting role for DOT1L in protecting UVR-induced melanomagenesis by facilitating DNA repair through interaction with XPC.
format article
author Bo Zhu
Shuyang Chen
Hongshen Wang
Chengqian Yin
Changpeng Han
Cong Peng
Zhaoqian Liu
Lixin Wan
Xiaoyang Zhang
Jie Zhang
Christine G. Lian
Peilin Ma
Zhi-xiang Xu
Sharon Prince
Tao Wang
Xiumei Gao
Yujiang Shi
Dali Liu
Min Liu
Wenyi Wei
Zhi Wei
Jingxuan Pan
Yongjun Wang
Zhenyu Xuan
Jay Hess
Nicholas K. Hayward
Colin R. Goding
Xiang Chen
Jun Zhou
Rutao Cui
author_facet Bo Zhu
Shuyang Chen
Hongshen Wang
Chengqian Yin
Changpeng Han
Cong Peng
Zhaoqian Liu
Lixin Wan
Xiaoyang Zhang
Jie Zhang
Christine G. Lian
Peilin Ma
Zhi-xiang Xu
Sharon Prince
Tao Wang
Xiumei Gao
Yujiang Shi
Dali Liu
Min Liu
Wenyi Wei
Zhi Wei
Jingxuan Pan
Yongjun Wang
Zhenyu Xuan
Jay Hess
Nicholas K. Hayward
Colin R. Goding
Xiang Chen
Jun Zhou
Rutao Cui
author_sort Bo Zhu
title The protective role of DOT1L in UV-induced melanomagenesis
title_short The protective role of DOT1L in UV-induced melanomagenesis
title_full The protective role of DOT1L in UV-induced melanomagenesis
title_fullStr The protective role of DOT1L in UV-induced melanomagenesis
title_full_unstemmed The protective role of DOT1L in UV-induced melanomagenesis
title_sort protective role of dot1l in uv-induced melanomagenesis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/2605881fd6234a65adf003e2d0a77077
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