Calcitonin gene related peptide α is dispensable for many danger-related motivational responses

Abstract Calcitonin gene related peptide (CGRP) expressing neurons in the parabrachial nucleus have been shown to encode danger. Through projections to the amygdala and other forebrain structures, they regulate food intake and trigger adaptive behaviors in response to threats like inflammation, into...

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Autores principales:	Joanna Zajdel, Johan Sköld, Maarit Jaarola, Anand Kumar Singh, David Engblom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/260aeb86c6cd4cdebaf192f67425eb97
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spelling	oai:doaj.org-article:260aeb86c6cd4cdebaf192f67425eb972021-12-02T18:50:44ZCalcitonin gene related peptide α is dispensable for many danger-related motivational responses10.1038/s41598-021-95670-82045-2322https://doaj.org/article/260aeb86c6cd4cdebaf192f67425eb972021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95670-8https://doaj.org/toc/2045-2322Abstract Calcitonin gene related peptide (CGRP) expressing neurons in the parabrachial nucleus have been shown to encode danger. Through projections to the amygdala and other forebrain structures, they regulate food intake and trigger adaptive behaviors in response to threats like inflammation, intoxication, tumors and pain. Despite the fact that this danger-encoding neuronal population has been defined based on its CGRP expression, it is not clear if CGRP is critical for its function. It is also not clear if CGRP in other neuronal structures is involved in danger-encoding. To examine the role of CGRP in danger-related motivational responses, we used male and female mice lacking αCGRP, which is the main form of CGRP in the brain. These mice had no, or only very weak, CGRP expression. Despite this, they did not behave differently compared to wildtype mice when they were tested for a battery of danger-related responses known to be mediated by CGRP neurons in the parabrachial nucleus. Mice lacking αCGRP and wildtype mice showed similar inflammation-induced anorexia, conditioned taste aversion, aversion to thermal pain and pain-induced escape behavior, although it should be pointed out that the study was not powered to detect any possible differences that were minor or sex-specific. Collectively, our findings suggest that αCGRP is not necessary for many threat-related responses, including some that are known to be mediated by CGRP neurons in the parabrachial nucleus.Joanna ZajdelJohan SköldMaarit JaarolaAnand Kumar SinghDavid EngblomNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joanna Zajdel Johan Sköld Maarit Jaarola Anand Kumar Singh David Engblom Calcitonin gene related peptide α is dispensable for many danger-related motivational responses
description	Abstract Calcitonin gene related peptide (CGRP) expressing neurons in the parabrachial nucleus have been shown to encode danger. Through projections to the amygdala and other forebrain structures, they regulate food intake and trigger adaptive behaviors in response to threats like inflammation, intoxication, tumors and pain. Despite the fact that this danger-encoding neuronal population has been defined based on its CGRP expression, it is not clear if CGRP is critical for its function. It is also not clear if CGRP in other neuronal structures is involved in danger-encoding. To examine the role of CGRP in danger-related motivational responses, we used male and female mice lacking αCGRP, which is the main form of CGRP in the brain. These mice had no, or only very weak, CGRP expression. Despite this, they did not behave differently compared to wildtype mice when they were tested for a battery of danger-related responses known to be mediated by CGRP neurons in the parabrachial nucleus. Mice lacking αCGRP and wildtype mice showed similar inflammation-induced anorexia, conditioned taste aversion, aversion to thermal pain and pain-induced escape behavior, although it should be pointed out that the study was not powered to detect any possible differences that were minor or sex-specific. Collectively, our findings suggest that αCGRP is not necessary for many threat-related responses, including some that are known to be mediated by CGRP neurons in the parabrachial nucleus.
format	article
author	Joanna Zajdel Johan Sköld Maarit Jaarola Anand Kumar Singh David Engblom
author_facet	Joanna Zajdel Johan Sköld Maarit Jaarola Anand Kumar Singh David Engblom
author_sort	Joanna Zajdel
title	Calcitonin gene related peptide α is dispensable for many danger-related motivational responses
title_short	Calcitonin gene related peptide α is dispensable for many danger-related motivational responses
title_full	Calcitonin gene related peptide α is dispensable for many danger-related motivational responses
title_fullStr	Calcitonin gene related peptide α is dispensable for many danger-related motivational responses
title_full_unstemmed	Calcitonin gene related peptide α is dispensable for many danger-related motivational responses
title_sort	calcitonin gene related peptide α is dispensable for many danger-related motivational responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/260aeb86c6cd4cdebaf192f67425eb97
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Calcitonin gene related peptide α is dispensable for many danger-related motivational responses

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