In vivo toxicities of the hospital effluent in Mahdia Tunisia

Hospital effluent (HE) is one of the most important sources of pharmaceuticals released into the environment. This kind of pollution is a recognized problem for both human health and aquatic life. Consequently, in the present study, we assessed the effects of untreated hospital effluent on mice via...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sabrine Afsa, Ons Fekih Sallem, Nouha Ben Abdeljelil, Anouar Feriani, Mohamed Fadhel Najjar, Hedi Ben Mansour
Formato:	article
Lenguaje:	EN
Publicado:	IWA Publishing 2021
Materias:	biochemical perturbation histopathology hospital effluent mice toxicity pharmaceuticals Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/260cb541eebd4e9b8c363968f9e1bcd3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:260cb541eebd4e9b8c363968f9e1bcd3
record_format	dspace
spelling	oai:doaj.org-article:260cb541eebd4e9b8c363968f9e1bcd32021-11-06T06:05:18ZIn vivo toxicities of the hospital effluent in Mahdia Tunisia1477-89201996-782910.2166/wh.2021.024https://doaj.org/article/260cb541eebd4e9b8c363968f9e1bcd32021-06-01T00:00:00Zhttp://jwh.iwaponline.com/content/19/3/499https://doaj.org/toc/1477-8920https://doaj.org/toc/1996-7829Hospital effluent (HE) is one of the most important sources of pharmaceuticals released into the environment. This kind of pollution is a recognized problem for both human health and aquatic life. Consequently, in the present study, we assessed the effects of untreated hospital effluent on mice via biochemical and histopathological determinations. Female mice were given free access to water bottles containing untreated HE at different dilutions for 21 days. Then clinical biochemistry and histopathology evaluation were conducted. Serum biochemistry analysis showed the presence of significant increase in cholesterol, triglycerides, glycaemia and total bilirubin. However, phosphatase alkaline and urea activities have been significantly decreased compared to the control group. No significant variation was observed for the rest of the studied parameters (high-density lipoproteins; low-density lipoproteins and uric acid). Additionally, multiple alterations, including cellular necrosis, leucocyte infiltration and congestion, were observed in different tissues of mice exposed to the tested HE. HIGHLIGHTS Hospital effluent (HE) exposure did not influence the total body weight of mice.; Sub-chronic exposure to the HE disturbed biochemical parameters in mice.; Histological abnormalities were observed in mice liver, kidney and heart sections.; Effluent toxicology.; Water contamination.;Sabrine AfsaOns Fekih SallemNouha Ben AbdeljelilAnouar FerianiMohamed Fadhel NajjarHedi Ben MansourIWA Publishingarticlebiochemical perturbationhistopathologyhospital effluentmice toxicitypharmaceuticalsPublic aspects of medicineRA1-1270ENJournal of Water and Health, Vol 19, Iss 3, Pp 499-511 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biochemical perturbation histopathology hospital effluent mice toxicity pharmaceuticals Public aspects of medicine RA1-1270
spellingShingle	biochemical perturbation histopathology hospital effluent mice toxicity pharmaceuticals Public aspects of medicine RA1-1270 Sabrine Afsa Ons Fekih Sallem Nouha Ben Abdeljelil Anouar Feriani Mohamed Fadhel Najjar Hedi Ben Mansour In vivo toxicities of the hospital effluent in Mahdia Tunisia
description	Hospital effluent (HE) is one of the most important sources of pharmaceuticals released into the environment. This kind of pollution is a recognized problem for both human health and aquatic life. Consequently, in the present study, we assessed the effects of untreated hospital effluent on mice via biochemical and histopathological determinations. Female mice were given free access to water bottles containing untreated HE at different dilutions for 21 days. Then clinical biochemistry and histopathology evaluation were conducted. Serum biochemistry analysis showed the presence of significant increase in cholesterol, triglycerides, glycaemia and total bilirubin. However, phosphatase alkaline and urea activities have been significantly decreased compared to the control group. No significant variation was observed for the rest of the studied parameters (high-density lipoproteins; low-density lipoproteins and uric acid). Additionally, multiple alterations, including cellular necrosis, leucocyte infiltration and congestion, were observed in different tissues of mice exposed to the tested HE. HIGHLIGHTS Hospital effluent (HE) exposure did not influence the total body weight of mice.; Sub-chronic exposure to the HE disturbed biochemical parameters in mice.; Histological abnormalities were observed in mice liver, kidney and heart sections.; Effluent toxicology.; Water contamination.;
format	article
author	Sabrine Afsa Ons Fekih Sallem Nouha Ben Abdeljelil Anouar Feriani Mohamed Fadhel Najjar Hedi Ben Mansour
author_facet	Sabrine Afsa Ons Fekih Sallem Nouha Ben Abdeljelil Anouar Feriani Mohamed Fadhel Najjar Hedi Ben Mansour
author_sort	Sabrine Afsa
title	In vivo toxicities of the hospital effluent in Mahdia Tunisia
title_short	In vivo toxicities of the hospital effluent in Mahdia Tunisia
title_full	In vivo toxicities of the hospital effluent in Mahdia Tunisia
title_fullStr	In vivo toxicities of the hospital effluent in Mahdia Tunisia
title_full_unstemmed	In vivo toxicities of the hospital effluent in Mahdia Tunisia
title_sort	in vivo toxicities of the hospital effluent in mahdia tunisia
publisher	IWA Publishing
publishDate	2021
url	https://doaj.org/article/260cb541eebd4e9b8c363968f9e1bcd3
work_keys_str_mv	AT sabrineafsa invivotoxicitiesofthehospitaleffluentinmahdiatunisia AT onsfekihsallem invivotoxicitiesofthehospitaleffluentinmahdiatunisia AT nouhabenabdeljelil invivotoxicitiesofthehospitaleffluentinmahdiatunisia AT anouarferiani invivotoxicitiesofthehospitaleffluentinmahdiatunisia AT mohamedfadhelnajjar invivotoxicitiesofthehospitaleffluentinmahdiatunisia AT hedibenmansour invivotoxicitiesofthehospitaleffluentinmahdiatunisia
_version_	1718443841793556480

In vivo toxicities of the hospital effluent in Mahdia Tunisia

Ejemplares similares