Communication between cells: exosomes as a delivery system in prostate cancer

Abstract Despite the considerable efforts in screening and diagnostic protocols, prostate cancer still represents the second leading cause of cancer-related death in men. Many patients with localized disease and low risk of recurrence have a favourable outcome. In a substantial proportion of patient...

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Autores principales:	Pia Giovannelli, Marzia Di Donato, Giovanni Galasso, Alessandra Monaco, Fabrizio Licitra, Bruno Perillo, Antimo Migliaccio, Gabriella Castoria
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Prostate cancer Tumor microenvironment Exosomes Diagnostic guidance Therapeutic applications Medicine R Cytology QH573-671
Acceso en línea:	https://doaj.org/article/260cb9001a554c26b0ad105d1deaacdd
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spelling	oai:doaj.org-article:260cb9001a554c26b0ad105d1deaacdd2021-11-14T12:15:35ZCommunication between cells: exosomes as a delivery system in prostate cancer10.1186/s12964-021-00792-11478-811Xhttps://doaj.org/article/260cb9001a554c26b0ad105d1deaacdd2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12964-021-00792-1https://doaj.org/toc/1478-811XAbstract Despite the considerable efforts in screening and diagnostic protocols, prostate cancer still represents the second leading cause of cancer-related death in men. Many patients with localized disease and low risk of recurrence have a favourable outcome. In a substantial proportion of patients, however, the disease progresses and becomes aggressive. The mechanisms that promote prostate cancer progression remain still debated. Many findings point to the role of cross-communication between prostate tumor cells and their surrounding microenvironment during the disease progression. Such a connection fosters survival, proliferation, angiogenesis, metastatic spreading and drug-resistance of prostate cancer. Recent years have seen a profound interest in understanding the way by which prostate cancer cells communicate with the surrounding cells in the microenvironment. In this regard, direct cell-to-cell contacts and soluble factors have been identified. Increasing evidence indicates that PC cells communicate with the surrounding cells through the release of extracellular vesicles, mainly the exosomes. By directly acting in stromal or prostate cancer epithelial cells, exosomes represent a critical intercellular communication system. By querying the public database ( https://pubmed.ncbi.nlm.nih.gov ) for the past 10 years, we have found more than four hundred papers. Among them, we have extrapolated the most relevant about the role of exosomes in prostate cancer malignancy and progression. Emerging data concerning the use of these vesicles in diagnostic management and therapeutic guidance of PC patients are also presented. Graphical Abstract Video AbstractPia GiovannelliMarzia Di DonatoGiovanni GalassoAlessandra MonacoFabrizio LicitraBruno PerilloAntimo MigliaccioGabriella CastoriaBMCarticleProstate cancerTumor microenvironmentExosomesDiagnostic guidanceTherapeutic applicationsMedicineRCytologyQH573-671ENCell Communication and Signaling, Vol 19, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prostate cancer Tumor microenvironment Exosomes Diagnostic guidance Therapeutic applications Medicine R Cytology QH573-671
spellingShingle	Prostate cancer Tumor microenvironment Exosomes Diagnostic guidance Therapeutic applications Medicine R Cytology QH573-671 Pia Giovannelli Marzia Di Donato Giovanni Galasso Alessandra Monaco Fabrizio Licitra Bruno Perillo Antimo Migliaccio Gabriella Castoria Communication between cells: exosomes as a delivery system in prostate cancer
description	Abstract Despite the considerable efforts in screening and diagnostic protocols, prostate cancer still represents the second leading cause of cancer-related death in men. Many patients with localized disease and low risk of recurrence have a favourable outcome. In a substantial proportion of patients, however, the disease progresses and becomes aggressive. The mechanisms that promote prostate cancer progression remain still debated. Many findings point to the role of cross-communication between prostate tumor cells and their surrounding microenvironment during the disease progression. Such a connection fosters survival, proliferation, angiogenesis, metastatic spreading and drug-resistance of prostate cancer. Recent years have seen a profound interest in understanding the way by which prostate cancer cells communicate with the surrounding cells in the microenvironment. In this regard, direct cell-to-cell contacts and soluble factors have been identified. Increasing evidence indicates that PC cells communicate with the surrounding cells through the release of extracellular vesicles, mainly the exosomes. By directly acting in stromal or prostate cancer epithelial cells, exosomes represent a critical intercellular communication system. By querying the public database ( https://pubmed.ncbi.nlm.nih.gov ) for the past 10 years, we have found more than four hundred papers. Among them, we have extrapolated the most relevant about the role of exosomes in prostate cancer malignancy and progression. Emerging data concerning the use of these vesicles in diagnostic management and therapeutic guidance of PC patients are also presented. Graphical Abstract Video Abstract
format	article
author	Pia Giovannelli Marzia Di Donato Giovanni Galasso Alessandra Monaco Fabrizio Licitra Bruno Perillo Antimo Migliaccio Gabriella Castoria
author_facet	Pia Giovannelli Marzia Di Donato Giovanni Galasso Alessandra Monaco Fabrizio Licitra Bruno Perillo Antimo Migliaccio Gabriella Castoria
author_sort	Pia Giovannelli
title	Communication between cells: exosomes as a delivery system in prostate cancer
title_short	Communication between cells: exosomes as a delivery system in prostate cancer
title_full	Communication between cells: exosomes as a delivery system in prostate cancer
title_fullStr	Communication between cells: exosomes as a delivery system in prostate cancer
title_full_unstemmed	Communication between cells: exosomes as a delivery system in prostate cancer
title_sort	communication between cells: exosomes as a delivery system in prostate cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/260cb9001a554c26b0ad105d1deaacdd
work_keys_str_mv	AT piagiovannelli communicationbetweencellsexosomesasadeliverysysteminprostatecancer AT marziadidonato communicationbetweencellsexosomesasadeliverysysteminprostatecancer AT giovannigalasso communicationbetweencellsexosomesasadeliverysysteminprostatecancer AT alessandramonaco communicationbetweencellsexosomesasadeliverysysteminprostatecancer AT fabriziolicitra communicationbetweencellsexosomesasadeliverysysteminprostatecancer AT brunoperillo communicationbetweencellsexosomesasadeliverysysteminprostatecancer AT antimomigliaccio communicationbetweencellsexosomesasadeliverysysteminprostatecancer AT gabriellacastoria communicationbetweencellsexosomesasadeliverysysteminprostatecancer
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Communication between cells: exosomes as a delivery system in prostate cancer

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