β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis

Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.

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Autores principales:	Silvia Giannini, Melissa M. Lee-Sundlov, Leonardo Rivadeneyra, Christian A. Di Buduo, Robert Burns, Joseph T. Lau, Hervé Falet, Alessandra Balduini, Karin M. Hoffmeister
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/260eeeaaa02b43dda46cc8c8f666fa3c
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spelling	oai:doaj.org-article:260eeeaaa02b43dda46cc8c8f666fa3c2021-12-02T15:39:27Zβ4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis10.1038/s41467-019-14178-y2041-1723https://doaj.org/article/260eeeaaa02b43dda46cc8c8f666fa3c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14178-yhttps://doaj.org/toc/2041-1723Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.Silvia GianniniMelissa M. Lee-SundlovLeonardo RivadeneyraChristian A. Di BuduoRobert BurnsJoseph T. LauHervé FaletAlessandra BalduiniKarin M. HoffmeisterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Giannini Melissa M. Lee-Sundlov Leonardo Rivadeneyra Christian A. Di Buduo Robert Burns Joseph T. Lau Hervé Falet Alessandra Balduini Karin M. Hoffmeister β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
description	Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.
format	article
author	Silvia Giannini Melissa M. Lee-Sundlov Leonardo Rivadeneyra Christian A. Di Buduo Robert Burns Joseph T. Lau Hervé Falet Alessandra Balduini Karin M. Hoffmeister
author_facet	Silvia Giannini Melissa M. Lee-Sundlov Leonardo Rivadeneyra Christian A. Di Buduo Robert Burns Joseph T. Lau Hervé Falet Alessandra Balduini Karin M. Hoffmeister
author_sort	Silvia Giannini
title	β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
title_short	β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
title_full	β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
title_fullStr	β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
title_full_unstemmed	β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
title_sort	β4galt1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/260eeeaaa02b43dda46cc8c8f666fa3c
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β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis

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