Crowding-induced opening of the mechanosensitive Piezo1 channel in silico

Mechanosensitive Piezo1 channels transduce mechanical stimuli into electrochemical signals. Jiang et al. show that due to the bending rigidity of the membrane, the overlap of neighboring Piezo1 footprints produces a flattening of the Piezo1 footprints and a cation-selective conducting pore. This stu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wenjuan Jiang, John Smith Del Rosario, Wesley Botello-Smith, Siyuan Zhao, Yi-chun Lin, Han Zhang, Jérôme Lacroix, Tibor Rohacs, Yun Lyna Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/260f5ac2fa9043ccbe7d6be853d3c43f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:260f5ac2fa9043ccbe7d6be853d3c43f
record_format	dspace
spelling	oai:doaj.org-article:260f5ac2fa9043ccbe7d6be853d3c43f2021-12-02T11:50:30ZCrowding-induced opening of the mechanosensitive Piezo1 channel in silico10.1038/s42003-020-01600-12399-3642https://doaj.org/article/260f5ac2fa9043ccbe7d6be853d3c43f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01600-1https://doaj.org/toc/2399-3642Mechanosensitive Piezo1 channels transduce mechanical stimuli into electrochemical signals. Jiang et al. show that due to the bending rigidity of the membrane, the overlap of neighboring Piezo1 footprints produces a flattening of the Piezo1 footprints and a cation-selective conducting pore. This study suggests that the clustering of Piezo1 channels may tune its sensitivity to applied force.Wenjuan JiangJohn Smith Del RosarioWesley Botello-SmithSiyuan ZhaoYi-chun LinHan ZhangJérôme LacroixTibor RohacsYun Lyna LuoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Wenjuan Jiang John Smith Del Rosario Wesley Botello-Smith Siyuan Zhao Yi-chun Lin Han Zhang Jérôme Lacroix Tibor Rohacs Yun Lyna Luo Crowding-induced opening of the mechanosensitive Piezo1 channel in silico
description	Mechanosensitive Piezo1 channels transduce mechanical stimuli into electrochemical signals. Jiang et al. show that due to the bending rigidity of the membrane, the overlap of neighboring Piezo1 footprints produces a flattening of the Piezo1 footprints and a cation-selective conducting pore. This study suggests that the clustering of Piezo1 channels may tune its sensitivity to applied force.
format	article
author	Wenjuan Jiang John Smith Del Rosario Wesley Botello-Smith Siyuan Zhao Yi-chun Lin Han Zhang Jérôme Lacroix Tibor Rohacs Yun Lyna Luo
author_facet	Wenjuan Jiang John Smith Del Rosario Wesley Botello-Smith Siyuan Zhao Yi-chun Lin Han Zhang Jérôme Lacroix Tibor Rohacs Yun Lyna Luo
author_sort	Wenjuan Jiang
title	Crowding-induced opening of the mechanosensitive Piezo1 channel in silico
title_short	Crowding-induced opening of the mechanosensitive Piezo1 channel in silico
title_full	Crowding-induced opening of the mechanosensitive Piezo1 channel in silico
title_fullStr	Crowding-induced opening of the mechanosensitive Piezo1 channel in silico
title_full_unstemmed	Crowding-induced opening of the mechanosensitive Piezo1 channel in silico
title_sort	crowding-induced opening of the mechanosensitive piezo1 channel in silico
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/260f5ac2fa9043ccbe7d6be853d3c43f
work_keys_str_mv	AT wenjuanjiang crowdinginducedopeningofthemechanosensitivepiezo1channelinsilico AT johnsmithdelrosario crowdinginducedopeningofthemechanosensitivepiezo1channelinsilico AT wesleybotellosmith crowdinginducedopeningofthemechanosensitivepiezo1channelinsilico AT siyuanzhao crowdinginducedopeningofthemechanosensitivepiezo1channelinsilico AT yichunlin crowdinginducedopeningofthemechanosensitivepiezo1channelinsilico AT hanzhang crowdinginducedopeningofthemechanosensitivepiezo1channelinsilico AT jeromelacroix crowdinginducedopeningofthemechanosensitivepiezo1channelinsilico AT tiborrohacs crowdinginducedopeningofthemechanosensitivepiezo1channelinsilico AT yunlynaluo crowdinginducedopeningofthemechanosensitivepiezo1channelinsilico
_version_	1718395152999907328

Crowding-induced opening of the mechanosensitive Piezo1 channel in silico

Ejemplares similares