Crowding-induced opening of the mechanosensitive Piezo1 channel in silico

Mechanosensitive Piezo1 channels transduce mechanical stimuli into electrochemical signals. Jiang et al. show that due to the bending rigidity of the membrane, the overlap of neighboring Piezo1 footprints produces a flattening of the Piezo1 footprints and a cation-selective conducting pore. This stu...

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Autores principales: Wenjuan Jiang, John Smith Del Rosario, Wesley Botello-Smith, Siyuan Zhao, Yi-chun Lin, Han Zhang, Jérôme Lacroix, Tibor Rohacs, Yun Lyna Luo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/260f5ac2fa9043ccbe7d6be853d3c43f
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