Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium

Abstract Cardiac magnetic resonance (CMR) spin-lattice relaxation time (T1) may be influenced by pathologic conditions due to changes in myocardial water content. We aimed to validate the principle and investigate T1 mapping at rest and adenosine stress to differentiate ischemic and infarcted myocar...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sirilak Yimcharoen, Shuo Zhang, Yodying Kaolawanich, Prajak Tanapibunpon, Rungroj Krittayaphong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2616459909534538a315e42110186279
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2616459909534538a315e42110186279
record_format	dspace
spelling	oai:doaj.org-article:2616459909534538a315e421101862792021-12-02T19:12:28ZClinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium10.1038/s41598-020-71722-32045-2322https://doaj.org/article/2616459909534538a315e421101862792020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-71722-3https://doaj.org/toc/2045-2322Abstract Cardiac magnetic resonance (CMR) spin-lattice relaxation time (T1) may be influenced by pathologic conditions due to changes in myocardial water content. We aimed to validate the principle and investigate T1 mapping at rest and adenosine stress to differentiate ischemic and infarcted myocardium from controls. Patients with suspected coronary artery disease who underwent CMR were prospectively recruited. Native rest and adenosine stress T1 maps were obtained using standard modified Look-Locker Inversion-Recovery technique. Among 181 patients included, T1 values were measured from three groups. In the control group, 72 patients showed myocardium with a T1 profile of 1,039 ± 75 ms at rest and a significant increase during stress (4.79 ± 3.14%, p < 0.001). While the ischemic (51 patients) and infarcted (58 patients) groups showed elevated resting T1 compared to controls (1,040 ± 90 ms for ischemic; 1,239 ± 121 ms for infarcted, p < 0.001), neither of which presented significant T1 reactivity (1.38 ± 3.02% for ischemic; 1.55 ± 5.25% for infarcted). We concluded that adenosine stress and rest T1 mapping may be useful to differentiate normal, ischemic and infarcted myocardium.Sirilak YimcharoenShuo ZhangYodying KaolawanichPrajak TanapibunponRungroj KrittayaphongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sirilak Yimcharoen Shuo Zhang Yodying Kaolawanich Prajak Tanapibunpon Rungroj Krittayaphong Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium
description	Abstract Cardiac magnetic resonance (CMR) spin-lattice relaxation time (T1) may be influenced by pathologic conditions due to changes in myocardial water content. We aimed to validate the principle and investigate T1 mapping at rest and adenosine stress to differentiate ischemic and infarcted myocardium from controls. Patients with suspected coronary artery disease who underwent CMR were prospectively recruited. Native rest and adenosine stress T1 maps were obtained using standard modified Look-Locker Inversion-Recovery technique. Among 181 patients included, T1 values were measured from three groups. In the control group, 72 patients showed myocardium with a T1 profile of 1,039 ± 75 ms at rest and a significant increase during stress (4.79 ± 3.14%, p < 0.001). While the ischemic (51 patients) and infarcted (58 patients) groups showed elevated resting T1 compared to controls (1,040 ± 90 ms for ischemic; 1,239 ± 121 ms for infarcted, p < 0.001), neither of which presented significant T1 reactivity (1.38 ± 3.02% for ischemic; 1.55 ± 5.25% for infarcted). We concluded that adenosine stress and rest T1 mapping may be useful to differentiate normal, ischemic and infarcted myocardium.
format	article
author	Sirilak Yimcharoen Shuo Zhang Yodying Kaolawanich Prajak Tanapibunpon Rungroj Krittayaphong
author_facet	Sirilak Yimcharoen Shuo Zhang Yodying Kaolawanich Prajak Tanapibunpon Rungroj Krittayaphong
author_sort	Sirilak Yimcharoen
title	Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium
title_short	Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium
title_full	Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium
title_fullStr	Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium
title_full_unstemmed	Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium
title_sort	clinical assessment of adenosine stress and rest cardiac magnetic resonance t1 mapping for detecting ischemic and infarcted myocardium
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2616459909534538a315e42110186279
work_keys_str_mv	AT sirilakyimcharoen clinicalassessmentofadenosinestressandrestcardiacmagneticresonancet1mappingfordetectingischemicandinfarctedmyocardium AT shuozhang clinicalassessmentofadenosinestressandrestcardiacmagneticresonancet1mappingfordetectingischemicandinfarctedmyocardium AT yodyingkaolawanich clinicalassessmentofadenosinestressandrestcardiacmagneticresonancet1mappingfordetectingischemicandinfarctedmyocardium AT prajaktanapibunpon clinicalassessmentofadenosinestressandrestcardiacmagneticresonancet1mappingfordetectingischemicandinfarctedmyocardium AT rungrojkrittayaphong clinicalassessmentofadenosinestressandrestcardiacmagneticresonancet1mappingfordetectingischemicandinfarctedmyocardium
_version_	1718377039936880640

Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium

Ejemplares similares