Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration

Summary: Recent studies suggest that a western diet may contribute to clinical neurodegeneration and dementia. Adipocyte-specific expression of the Na,K-ATPase signaling antagonist, NaKtide, ameliorates the pathophysiological consequences of murine experimental obesity and renal failure. In this stu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Komal Sodhi, Rebecca Pratt, Xiaoliang Wang, Hari Vishal Lakhani, Sneha S. Pillai, Mishghan Zehra, Jiayan Wang, Lawrence Grover, Brandon Henderson, James Denvir, Jiang Liu, Sandrine Pierre, Thomas Nelson, Joseph I. Shapiro
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Molecular physiology Neuroscience Cell biology Science Q
Acceso en línea:	https://doaj.org/article/2616f0730c0a41648e1183cee566289c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2616f0730c0a41648e1183cee566289c
record_format	dspace
spelling	oai:doaj.org-article:2616f0730c0a41648e1183cee566289c2021-11-20T05:09:00ZRole of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration2589-004210.1016/j.isci.2021.103262https://doaj.org/article/2616f0730c0a41648e1183cee566289c2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012311https://doaj.org/toc/2589-0042Summary: Recent studies suggest that a western diet may contribute to clinical neurodegeneration and dementia. Adipocyte-specific expression of the Na,K-ATPase signaling antagonist, NaKtide, ameliorates the pathophysiological consequences of murine experimental obesity and renal failure. In this study, we found that a western diet produced systemic oxidant stress along with evidence of activation of Na,K-ATPase signaling within both murine brain and peripheral tissues. We also noted this diet caused increases in circulating inflammatory cytokines as well as behavioral, and brain biochemical changes consistent with neurodegeneration. Adipocyte specific NaKtide affected by a doxycycline on/off expression system ameliorated all of these diet effects. These data suggest that a western diet produces cognitive decline and neurodegeneration through augmented Na,K-ATPase signaling and that antagonism of this pathway in adipocytes ameliorates the pathophysiology. If this observation is confirmed in humans, the adipocyte Na,K-ATPase may serve as a clinical target in the therapy of neurodegenerative disorders.Komal SodhiRebecca PrattXiaoliang WangHari Vishal LakhaniSneha S. PillaiMishghan ZehraJiayan WangLawrence GroverBrandon HendersonJames DenvirJiang LiuSandrine PierreThomas NelsonJoseph I. ShapiroElsevierarticleMolecular physiologyNeuroscienceCell biologyScienceQENiScience, Vol 24, Iss 11, Pp 103262- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Molecular physiology Neuroscience Cell biology Science Q
spellingShingle	Molecular physiology Neuroscience Cell biology Science Q Komal Sodhi Rebecca Pratt Xiaoliang Wang Hari Vishal Lakhani Sneha S. Pillai Mishghan Zehra Jiayan Wang Lawrence Grover Brandon Henderson James Denvir Jiang Liu Sandrine Pierre Thomas Nelson Joseph I. Shapiro Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
description	Summary: Recent studies suggest that a western diet may contribute to clinical neurodegeneration and dementia. Adipocyte-specific expression of the Na,K-ATPase signaling antagonist, NaKtide, ameliorates the pathophysiological consequences of murine experimental obesity and renal failure. In this study, we found that a western diet produced systemic oxidant stress along with evidence of activation of Na,K-ATPase signaling within both murine brain and peripheral tissues. We also noted this diet caused increases in circulating inflammatory cytokines as well as behavioral, and brain biochemical changes consistent with neurodegeneration. Adipocyte specific NaKtide affected by a doxycycline on/off expression system ameliorated all of these diet effects. These data suggest that a western diet produces cognitive decline and neurodegeneration through augmented Na,K-ATPase signaling and that antagonism of this pathway in adipocytes ameliorates the pathophysiology. If this observation is confirmed in humans, the adipocyte Na,K-ATPase may serve as a clinical target in the therapy of neurodegenerative disorders.
format	article
author	Komal Sodhi Rebecca Pratt Xiaoliang Wang Hari Vishal Lakhani Sneha S. Pillai Mishghan Zehra Jiayan Wang Lawrence Grover Brandon Henderson James Denvir Jiang Liu Sandrine Pierre Thomas Nelson Joseph I. Shapiro
author_facet	Komal Sodhi Rebecca Pratt Xiaoliang Wang Hari Vishal Lakhani Sneha S. Pillai Mishghan Zehra Jiayan Wang Lawrence Grover Brandon Henderson James Denvir Jiang Liu Sandrine Pierre Thomas Nelson Joseph I. Shapiro
author_sort	Komal Sodhi
title	Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
title_short	Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
title_full	Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
title_fullStr	Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
title_full_unstemmed	Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
title_sort	role of adipocyte na,k-atpase oxidant amplification loop in cognitive decline and neurodegeneration
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2616f0730c0a41648e1183cee566289c
work_keys_str_mv	AT komalsodhi roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT rebeccapratt roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT xiaoliangwang roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT harivishallakhani roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT snehaspillai roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT mishghanzehra roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT jiayanwang roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT lawrencegrover roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT brandonhenderson roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT jamesdenvir roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT jiangliu roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT sandrinepierre roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT thomasnelson roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration AT josephishapiro roleofadipocytenakatpaseoxidantamplificationloopincognitivedeclineandneurodegeneration
_version_	1718419531184996352

Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration

Ejemplares similares