A Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis

PurposeThe aim of the study was to compare the clinical outcomes of induction chemotherapy (IC) followed by definitive concurrent chemoradiotherapy (dCCRT) versus chemoradiotherapy alone in patients with esophageal squamous cell carcinoma (ESCC) on the basis of a clinical scoring model.MethodsA retr...

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Autores principales:	Yang Li, Qingwu Du, Xiaoying Wei, Zhoubo Guo, Tongda Lei, Yanqi Li, Dong Han, Xiaoyue Wu, Kunning Zhang, Tian Zhang, Xi Chen, Jie Dong, Baozhong Zhang, Hui Wei, Wencheng Zhang, Qingsong Pang, Ping Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	esophageal squamous cell carcinoma induction chemotherapy definitive concurrent chemoradiotherapy progression-free survival overall survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/261ad8ecc74746c38f83830b5b3b94b3
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spelling	oai:doaj.org-article:261ad8ecc74746c38f83830b5b3b94b32021-12-01T13:13:53ZA Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis2234-943X10.3389/fonc.2021.703074https://doaj.org/article/261ad8ecc74746c38f83830b5b3b94b32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.703074/fullhttps://doaj.org/toc/2234-943XPurposeThe aim of the study was to compare the clinical outcomes of induction chemotherapy (IC) followed by definitive concurrent chemoradiotherapy (dCCRT) versus chemoradiotherapy alone in patients with esophageal squamous cell carcinoma (ESCC) on the basis of a clinical scoring model.MethodsA retrospective review of 599 patients with ESCC treated with dCCRT at our institution from 2010 to 2019 was conducted. The patients were divided into two groups based on whether they received IC. A clinical scoring model was performed using the significant variables obtained from the multivariate analysis. The PFS and OS rates were estimated using the Kaplan–Meier method.ResultsDuring the study period, 182 patients receiving IC followed by dCCRT and 417 dCCRT alone were identified. No significant differences in the PFS and OS rates were observed between the IC group (P=0.532) and the non-IC group (P=0.078). A clinical scoring model was constructed based on independent prognostic factors with scores ranging from 0 to 10.4. The patients were divided into high- and low-risk groups by using the median score as the cutoff value. The PFS rate of patients receiving IC was higher than that of patients treated without IC (P=0.034), while there was no improvement in the OS rate (P=0.794) in the high-risk group. No significant differences in the PFS (P=0.207) or OS (P=0.997) rate were found between the two treatment groups in the low-risk group.ConclusionsThe addition of IC followed by dCCRT for patients with ESCC might be associated with better PFS rates based on a clinical scoring model but has no impact on OS rates. Further prospective studies are warranted for the validation of this model.Yang LiQingwu DuXiaoying WeiZhoubo GuoTongda LeiYanqi LiDong HanXiaoyue WuKunning ZhangTian ZhangXi ChenJie DongBaozhong ZhangHui WeiWencheng ZhangQingsong PangPing WangFrontiers Media S.A.articleesophageal squamous cell carcinomainduction chemotherapydefinitive concurrent chemoradiotherapyprogression-free survivaloverall survivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	esophageal squamous cell carcinoma induction chemotherapy definitive concurrent chemoradiotherapy progression-free survival overall survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	esophageal squamous cell carcinoma induction chemotherapy definitive concurrent chemoradiotherapy progression-free survival overall survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yang Li Qingwu Du Xiaoying Wei Zhoubo Guo Tongda Lei Yanqi Li Dong Han Xiaoyue Wu Kunning Zhang Tian Zhang Xi Chen Jie Dong Baozhong Zhang Hui Wei Wencheng Zhang Qingsong Pang Ping Wang A Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis
description	PurposeThe aim of the study was to compare the clinical outcomes of induction chemotherapy (IC) followed by definitive concurrent chemoradiotherapy (dCCRT) versus chemoradiotherapy alone in patients with esophageal squamous cell carcinoma (ESCC) on the basis of a clinical scoring model.MethodsA retrospective review of 599 patients with ESCC treated with dCCRT at our institution from 2010 to 2019 was conducted. The patients were divided into two groups based on whether they received IC. A clinical scoring model was performed using the significant variables obtained from the multivariate analysis. The PFS and OS rates were estimated using the Kaplan–Meier method.ResultsDuring the study period, 182 patients receiving IC followed by dCCRT and 417 dCCRT alone were identified. No significant differences in the PFS and OS rates were observed between the IC group (P=0.532) and the non-IC group (P=0.078). A clinical scoring model was constructed based on independent prognostic factors with scores ranging from 0 to 10.4. The patients were divided into high- and low-risk groups by using the median score as the cutoff value. The PFS rate of patients receiving IC was higher than that of patients treated without IC (P=0.034), while there was no improvement in the OS rate (P=0.794) in the high-risk group. No significant differences in the PFS (P=0.207) or OS (P=0.997) rate were found between the two treatment groups in the low-risk group.ConclusionsThe addition of IC followed by dCCRT for patients with ESCC might be associated with better PFS rates based on a clinical scoring model but has no impact on OS rates. Further prospective studies are warranted for the validation of this model.
format	article
author	Yang Li Qingwu Du Xiaoying Wei Zhoubo Guo Tongda Lei Yanqi Li Dong Han Xiaoyue Wu Kunning Zhang Tian Zhang Xi Chen Jie Dong Baozhong Zhang Hui Wei Wencheng Zhang Qingsong Pang Ping Wang
author_facet	Yang Li Qingwu Du Xiaoying Wei Zhoubo Guo Tongda Lei Yanqi Li Dong Han Xiaoyue Wu Kunning Zhang Tian Zhang Xi Chen Jie Dong Baozhong Zhang Hui Wei Wencheng Zhang Qingsong Pang Ping Wang
author_sort	Yang Li
title	A Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis
title_short	A Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis
title_full	A Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis
title_fullStr	A Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis
title_full_unstemmed	A Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis
title_sort	clinical scoring model to predict the effect of induction chemotherapy with definitive concurrent chemoradiotherapy on esophageal squamous cell carcinoma prognosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/261ad8ecc74746c38f83830b5b3b94b3
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A Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis

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