Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved

Karel Allegaert1,2 1Intensive Care, Department of Surgery, Erasmus MC Sophia Children’s Hospital, Rotterdam, the Netherlands; 2Department of Development and Regeneration, KU Leuven, BelgiumI read, with great interest, the paper on the intraocular pressure-lowering properties of i...

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Autor principal:	Allegaert K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	paracetamol intraocular pressure mannitol excipient Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/261d634b51ac498bbe5086274457fecd
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spelling	oai:doaj.org-article:261d634b51ac498bbe5086274457fecd2021-12-02T07:34:16ZIntravenous paracetamol and intraocular pressure reduction: mannitol may also be involved1177-5483https://doaj.org/article/261d634b51ac498bbe5086274457fecd2016-09-01T00:00:00Zhttps://www.dovepress.com/intravenous-paracetamol-and-intraocular-pressure-reduction-mannitol-ma-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Karel Allegaert1,2 1Intensive Care, Department of Surgery, Erasmus MC Sophia Children’s Hospital, Rotterdam, the Netherlands; 2Department of Development and Regeneration, KU Leuven, BelgiumI read, with great interest, the paper on the intraocular pressure-lowering properties of intravenous paracetamol (acetaminophen) recently published in this journal by van den Heever and Meyer.1 The authors documented a decrease from baseline in mean intraocular pressure of 15.7% in a 6-hour time interval following intravenous paracetamol (1 g Perfalgan®, Bristol-Myers Squibb, New York, NY, USA) administration. This mean decrease was moderate but relevant when compared to, for example, topical timolol (–25.3%, single drop 0.5% timolol maleate) or oral acetazolamide (–23.1%, 250 mg). Although the authors provided potential relevant mechanistic arguments in support of a link between paracetamol administration and intraocular pressure through the endocannabinoid system, we would like to draw attention to the fact that – when intravenous paracetamol is administered – a relevant amount of mannitol is coadministered.View the original paper by van den Heever and MeyerAllegaert KDove Medical Pressarticleparacetamolintraocular pressuremannitolexcipientOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 1775-1777 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	paracetamol intraocular pressure mannitol excipient Ophthalmology RE1-994
spellingShingle	paracetamol intraocular pressure mannitol excipient Ophthalmology RE1-994 Allegaert K Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved
description	Karel Allegaert1,2 1Intensive Care, Department of Surgery, Erasmus MC Sophia Children’s Hospital, Rotterdam, the Netherlands; 2Department of Development and Regeneration, KU Leuven, BelgiumI read, with great interest, the paper on the intraocular pressure-lowering properties of intravenous paracetamol (acetaminophen) recently published in this journal by van den Heever and Meyer.1 The authors documented a decrease from baseline in mean intraocular pressure of 15.7% in a 6-hour time interval following intravenous paracetamol (1 g Perfalgan®, Bristol-Myers Squibb, New York, NY, USA) administration. This mean decrease was moderate but relevant when compared to, for example, topical timolol (–25.3%, single drop 0.5% timolol maleate) or oral acetazolamide (–23.1%, 250 mg). Although the authors provided potential relevant mechanistic arguments in support of a link between paracetamol administration and intraocular pressure through the endocannabinoid system, we would like to draw attention to the fact that – when intravenous paracetamol is administered – a relevant amount of mannitol is coadministered.View the original paper by van den Heever and Meyer
format	article
author	Allegaert K
author_facet	Allegaert K
author_sort	Allegaert K
title	Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved
title_short	Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved
title_full	Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved
title_fullStr	Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved
title_full_unstemmed	Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved
title_sort	intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/261d634b51ac498bbe5086274457fecd
work_keys_str_mv	AT allegaertk intravenousparacetamolandintraocularpressurereductionmannitolmayalsobeinvolved
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Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved

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