Arterial stiffening provides sufficient explanation for primary hypertension.

Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Klas H Pettersen, Scott M Bugenhagen, Javaid Nauman, Daniel A Beard, Stig W Omholt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/261f1dc6c8c64bf694460bedc44d6ab3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:261f1dc6c8c64bf694460bedc44d6ab3
record_format	dspace
spelling	oai:doaj.org-article:261f1dc6c8c64bf694460bedc44d6ab32021-11-11T05:52:09ZArterial stiffening provides sufficient explanation for primary hypertension.1553-734X1553-735810.1371/journal.pcbi.1003634https://doaj.org/article/261f1dc6c8c64bf694460bedc44d6ab32014-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24853828/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergence of hypertension. Specifically, the empirically observed chronic changes in pulse pressure with age and the impaired capacity of hypertensive individuals to regulate short-term changes in blood pressure arise as emergent properties of the integrated system. The results are consistent with available experimental data from chemical and surgical manipulation of the cardio-vascular system. In contrast to widely held opinions, the results suggest that primary hypertension can be attributed to a mechanogenic etiology without challenging current conceptions of renal and sympathetic nervous system function.Klas H PettersenScott M BugenhagenJavaid NaumanDaniel A BeardStig W OmholtPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 10, Iss 5, p e1003634 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Klas H Pettersen Scott M Bugenhagen Javaid Nauman Daniel A Beard Stig W Omholt Arterial stiffening provides sufficient explanation for primary hypertension.
description	Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergence of hypertension. Specifically, the empirically observed chronic changes in pulse pressure with age and the impaired capacity of hypertensive individuals to regulate short-term changes in blood pressure arise as emergent properties of the integrated system. The results are consistent with available experimental data from chemical and surgical manipulation of the cardio-vascular system. In contrast to widely held opinions, the results suggest that primary hypertension can be attributed to a mechanogenic etiology without challenging current conceptions of renal and sympathetic nervous system function.
format	article
author	Klas H Pettersen Scott M Bugenhagen Javaid Nauman Daniel A Beard Stig W Omholt
author_facet	Klas H Pettersen Scott M Bugenhagen Javaid Nauman Daniel A Beard Stig W Omholt
author_sort	Klas H Pettersen
title	Arterial stiffening provides sufficient explanation for primary hypertension.
title_short	Arterial stiffening provides sufficient explanation for primary hypertension.
title_full	Arterial stiffening provides sufficient explanation for primary hypertension.
title_fullStr	Arterial stiffening provides sufficient explanation for primary hypertension.
title_full_unstemmed	Arterial stiffening provides sufficient explanation for primary hypertension.
title_sort	arterial stiffening provides sufficient explanation for primary hypertension.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/261f1dc6c8c64bf694460bedc44d6ab3
work_keys_str_mv	AT klashpettersen arterialstiffeningprovidessufficientexplanationforprimaryhypertension AT scottmbugenhagen arterialstiffeningprovidessufficientexplanationforprimaryhypertension AT javaidnauman arterialstiffeningprovidessufficientexplanationforprimaryhypertension AT danielabeard arterialstiffeningprovidessufficientexplanationforprimaryhypertension AT stigwomholt arterialstiffeningprovidessufficientexplanationforprimaryhypertension
_version_	1718439470540259328

Arterial stiffening provides sufficient explanation for primary hypertension.

Ejemplares similares