Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5

The orphan GPR158 receptor belongs to the class C GPCR family and interacts with the regulator of G protein signaling 7 (RGS7)-Gβ5 complex. Here, the authors present the cryo-EM structure of human GPR158, which reveals that the extracellular domain contains a PAS domain, and they also determine the...

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Autores principales:	Eunyoung Jeong, Yoojoong Kim, Jihong Jeong, Yunje Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2623a5e0e5344370bd993811784515c1
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spelling	oai:doaj.org-article:2623a5e0e5344370bd993811784515c12021-11-28T12:32:11ZStructure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ510.1038/s41467-021-27147-12041-1723https://doaj.org/article/2623a5e0e5344370bd993811784515c12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27147-1https://doaj.org/toc/2041-1723The orphan GPR158 receptor belongs to the class C GPCR family and interacts with the regulator of G protein signaling 7 (RGS7)-Gβ5 complex. Here, the authors present the cryo-EM structure of human GPR158, which reveals that the extracellular domain contains a PAS domain, and they also determine the structures of GPR158 in complex with either one or two RGS7-Gβ5 heterodimers and discuss implications for the signaling mechanism.Eunyoung JeongYoojoong KimJihong JeongYunje ChoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eunyoung Jeong Yoojoong Kim Jihong Jeong Yunje Cho Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
description	The orphan GPR158 receptor belongs to the class C GPCR family and interacts with the regulator of G protein signaling 7 (RGS7)-Gβ5 complex. Here, the authors present the cryo-EM structure of human GPR158, which reveals that the extracellular domain contains a PAS domain, and they also determine the structures of GPR158 in complex with either one or two RGS7-Gβ5 heterodimers and discuss implications for the signaling mechanism.
format	article
author	Eunyoung Jeong Yoojoong Kim Jihong Jeong Yunje Cho
author_facet	Eunyoung Jeong Yoojoong Kim Jihong Jeong Yunje Cho
author_sort	Eunyoung Jeong
title	Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
title_short	Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
title_full	Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
title_fullStr	Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
title_full_unstemmed	Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
title_sort	structure of the class c orphan gpcr gpr158 in complex with rgs7-gβ5
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2623a5e0e5344370bd993811784515c1
work_keys_str_mv	AT eunyoungjeong structureoftheclasscorphangpcrgpr158incomplexwithrgs7gb5 AT yoojoongkim structureoftheclasscorphangpcrgpr158incomplexwithrgs7gb5 AT jihongjeong structureoftheclasscorphangpcrgpr158incomplexwithrgs7gb5 AT yunjecho structureoftheclasscorphangpcrgpr158incomplexwithrgs7gb5
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Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5

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