Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.

<h4>Background</h4>Irritable bowel syndrome (IBS) is a multi-faceted gastrointestinal disorder where food intake often triggers symptoms. Metabolomics may provide mechanistical insights to why responses to dietary modifications are diverse.<h4>Objective</h4>This study aimed t...

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Autores principales:	Sanna Nybacka, Magnus Simrén, Stine Störsrud, Hans Törnblom, Anna Winkvist, Helen M Lindqvist
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2629e9d0e92b4cb89bb05b98305be98a
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spelling	oai:doaj.org-article:2629e9d0e92b4cb89bb05b98305be98a2021-12-02T20:17:06ZChanges in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.1932-620310.1371/journal.pone.0257331https://doaj.org/article/2629e9d0e92b4cb89bb05b98305be98a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257331https://doaj.org/toc/1932-6203<h4>Background</h4>Irritable bowel syndrome (IBS) is a multi-faceted gastrointestinal disorder where food intake often triggers symptoms. Metabolomics may provide mechanistical insights to why responses to dietary modifications are diverse.<h4>Objective</h4>This study aimed to identify metabolite patterns related to dietary intake in patients with IBS, and to identify metabolites driving the separation between responders and non-responders to treatment.<h4>Methods</h4>Participants were randomized to a low fermentable oligo-, di-, monosaccharide and polyol (FODMAP) diet (LFD) or traditional IBS diet (TID) for four weeks. Fasting serum and urine samples pre- and post-intervention were analyzed using 1H nuclear magnetic resonance (NMR) metabolomics. Response to treatment was defined as a reduction in IBS severity scoring system (IBS-SSS) ≥50.<h4>Results</h4>Twenty-five individuals in the LFD (13 responders) and 28 in the TID (14 responders) were included in these post hoc analyses. In endpoint samples, significant decreases in polyols and glucose were seen in the LFD. Post-intervention samples revealed that LFD responders had significantly increased levels of 2-hydroxybuturate and decreased levels of glucose and pantothenic acid compared to non-responders. For the TID, only weak multivariate models were identified and a larger diversity in metabolite response compared to the LFD were noted.<h4>Conclusions</h4>In this study, metabolite patterns between individuals who responded well to an LFD compared to non-responders could be distinguished. This provides new hypotheses for mechanistic actions related to response to dietary modifications, but the results need to be validated in larger cohorts.<h4>Clinical trial registration</h4>This trial was registered at www.clinicaltrials.gov, registry number NCT02107625.Sanna NybackaMagnus SimrénStine StörsrudHans TörnblomAnna WinkvistHelen M LindqvistPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257331 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanna Nybacka Magnus Simrén Stine Störsrud Hans Törnblom Anna Winkvist Helen M Lindqvist Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.
description	<h4>Background</h4>Irritable bowel syndrome (IBS) is a multi-faceted gastrointestinal disorder where food intake often triggers symptoms. Metabolomics may provide mechanistical insights to why responses to dietary modifications are diverse.<h4>Objective</h4>This study aimed to identify metabolite patterns related to dietary intake in patients with IBS, and to identify metabolites driving the separation between responders and non-responders to treatment.<h4>Methods</h4>Participants were randomized to a low fermentable oligo-, di-, monosaccharide and polyol (FODMAP) diet (LFD) or traditional IBS diet (TID) for four weeks. Fasting serum and urine samples pre- and post-intervention were analyzed using 1H nuclear magnetic resonance (NMR) metabolomics. Response to treatment was defined as a reduction in IBS severity scoring system (IBS-SSS) ≥50.<h4>Results</h4>Twenty-five individuals in the LFD (13 responders) and 28 in the TID (14 responders) were included in these post hoc analyses. In endpoint samples, significant decreases in polyols and glucose were seen in the LFD. Post-intervention samples revealed that LFD responders had significantly increased levels of 2-hydroxybuturate and decreased levels of glucose and pantothenic acid compared to non-responders. For the TID, only weak multivariate models were identified and a larger diversity in metabolite response compared to the LFD were noted.<h4>Conclusions</h4>In this study, metabolite patterns between individuals who responded well to an LFD compared to non-responders could be distinguished. This provides new hypotheses for mechanistic actions related to response to dietary modifications, but the results need to be validated in larger cohorts.<h4>Clinical trial registration</h4>This trial was registered at www.clinicaltrials.gov, registry number NCT02107625.
format	article
author	Sanna Nybacka Magnus Simrén Stine Störsrud Hans Törnblom Anna Winkvist Helen M Lindqvist
author_facet	Sanna Nybacka Magnus Simrén Stine Störsrud Hans Törnblom Anna Winkvist Helen M Lindqvist
author_sort	Sanna Nybacka
title	Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.
title_short	Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.
title_full	Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.
title_fullStr	Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.
title_full_unstemmed	Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.
title_sort	changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2629e9d0e92b4cb89bb05b98305be98a
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Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.

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