aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability
The cell polarity regulator aPKC is associated with cell proliferation but the precise mechanism are unknown. Here, the authors find that aPKC lambda phosphorylates the FoxO1 transcription factor, a gatekeeper of endothelial growth, during both angiogenesis and angiosarcomas.
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| Lenguaje: | EN |
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/262aa7beda84463ca8dfda4862f93e83 |
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oai:doaj.org-article:262aa7beda84463ca8dfda4862f93e832021-12-02T14:38:51ZaPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability10.1038/s41467-018-07739-02041-1723https://doaj.org/article/262aa7beda84463ca8dfda4862f93e832018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07739-0https://doaj.org/toc/2041-1723The cell polarity regulator aPKC is associated with cell proliferation but the precise mechanism are unknown. Here, the authors find that aPKC lambda phosphorylates the FoxO1 transcription factor, a gatekeeper of endothelial growth, during both angiogenesis and angiosarcomas.Meghan RiddellAkiko NakayamaTakao HikitaFatemeh MirzapourshafiyiTakuji KawamuraAyesha PashaMengnan LiMikio MasuzawaMario LoosoTim SteinbacherKlaus EbnetMichael PotenteTomonori HiroseShigeo OhnoIngrid FlemingStefan GattenlöhnerPhyu P. AungThuy PhungOsamu YamasakiTeruki YanagiHiroshi UmemuraMasanori NakayamaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Meghan Riddell Akiko Nakayama Takao Hikita Fatemeh Mirzapourshafiyi Takuji Kawamura Ayesha Pasha Mengnan Li Mikio Masuzawa Mario Looso Tim Steinbacher Klaus Ebnet Michael Potente Tomonori Hirose Shigeo Ohno Ingrid Fleming Stefan Gattenlöhner Phyu P. Aung Thuy Phung Osamu Yamasaki Teruki Yanagi Hiroshi Umemura Masanori Nakayama aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability |
| description |
The cell polarity regulator aPKC is associated with cell proliferation but the precise mechanism are unknown. Here, the authors find that aPKC lambda phosphorylates the FoxO1 transcription factor, a gatekeeper of endothelial growth, during both angiogenesis and angiosarcomas. |
| format |
article |
| author |
Meghan Riddell Akiko Nakayama Takao Hikita Fatemeh Mirzapourshafiyi Takuji Kawamura Ayesha Pasha Mengnan Li Mikio Masuzawa Mario Looso Tim Steinbacher Klaus Ebnet Michael Potente Tomonori Hirose Shigeo Ohno Ingrid Fleming Stefan Gattenlöhner Phyu P. Aung Thuy Phung Osamu Yamasaki Teruki Yanagi Hiroshi Umemura Masanori Nakayama |
| author_facet |
Meghan Riddell Akiko Nakayama Takao Hikita Fatemeh Mirzapourshafiyi Takuji Kawamura Ayesha Pasha Mengnan Li Mikio Masuzawa Mario Looso Tim Steinbacher Klaus Ebnet Michael Potente Tomonori Hirose Shigeo Ohno Ingrid Fleming Stefan Gattenlöhner Phyu P. Aung Thuy Phung Osamu Yamasaki Teruki Yanagi Hiroshi Umemura Masanori Nakayama |
| author_sort |
Meghan Riddell |
| title |
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability |
| title_short |
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability |
| title_full |
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability |
| title_fullStr |
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability |
| title_full_unstemmed |
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability |
| title_sort |
apkc controls endothelial growth by modulating c-myc via foxo1 dna-binding ability |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/262aa7beda84463ca8dfda4862f93e83 |
| work_keys_str_mv |
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