DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy

Abstract Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment. Although there are more than 15 AEDs available, a third of epilepsy patients remain refractory to available drugs, so novel effective drugs are needed...

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Autores principales:	Min Xu, Peng Sun, Ying Zhang, Ci-Hang Yang, Xin Wei, Xiao-Xia Ma, Chong-Ren Yang, Kun-Ming Ni, Ying-Jun Zhang, Xiao-Ming Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/262e15715b8d47d3acb69d6fe2b3a24a
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spelling	oai:doaj.org-article:262e15715b8d47d3acb69d6fe2b3a24a2021-12-02T15:04:58ZDV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy10.1038/s41598-017-01734-z2045-2322https://doaj.org/article/262e15715b8d47d3acb69d6fe2b3a24a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01734-zhttps://doaj.org/toc/2045-2322Abstract Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment. Although there are more than 15 AEDs available, a third of epilepsy patients remain refractory to available drugs, so novel effective drugs are needed. Here, we found that DV21, which is a natural triterpenoid compound extracted from plants of the Asclepiadaceae family, significantly decreased the incidence and stages of seizures in three classical drug-induced acute seizure models in C57BL/6 mice. Furthermore, we also found that the antiepileptic effect of DV21 might be partly mediated through reducing the excitability of cortical pyramidal neurons by increasing M current, which are low-threshold non-inactivating voltage-gated potassium currents. Moreover, the application of XE991, an inhibitor of M current, could block most the antiepileptic effect of DV21. Taken together, our results indicated that DV21 might be a novel leading compound for the treatment of epilepsy.Min XuPeng SunYing ZhangCi-Hang YangXin WeiXiao-Xia MaChong-Ren YangKun-Ming NiYing-Jun ZhangXiao-Ming LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Xu Peng Sun Ying Zhang Ci-Hang Yang Xin Wei Xiao-Xia Ma Chong-Ren Yang Kun-Ming Ni Ying-Jun Zhang Xiao-Ming Li DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy
description	Abstract Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment. Although there are more than 15 AEDs available, a third of epilepsy patients remain refractory to available drugs, so novel effective drugs are needed. Here, we found that DV21, which is a natural triterpenoid compound extracted from plants of the Asclepiadaceae family, significantly decreased the incidence and stages of seizures in three classical drug-induced acute seizure models in C57BL/6 mice. Furthermore, we also found that the antiepileptic effect of DV21 might be partly mediated through reducing the excitability of cortical pyramidal neurons by increasing M current, which are low-threshold non-inactivating voltage-gated potassium currents. Moreover, the application of XE991, an inhibitor of M current, could block most the antiepileptic effect of DV21. Taken together, our results indicated that DV21 might be a novel leading compound for the treatment of epilepsy.
format	article
author	Min Xu Peng Sun Ying Zhang Ci-Hang Yang Xin Wei Xiao-Xia Ma Chong-Ren Yang Kun-Ming Ni Ying-Jun Zhang Xiao-Ming Li
author_facet	Min Xu Peng Sun Ying Zhang Ci-Hang Yang Xin Wei Xiao-Xia Ma Chong-Ren Yang Kun-Ming Ni Ying-Jun Zhang Xiao-Ming Li
author_sort	Min Xu
title	DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy
title_short	DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy
title_full	DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy
title_fullStr	DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy
title_full_unstemmed	DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy
title_sort	dv21 decreases excitability of cortical pyramidal neurons and acts in epilepsy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/262e15715b8d47d3acb69d6fe2b3a24a
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DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy

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