Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay

Compounds that contain alkyl-difluoromethyl moieties are of interest for medicinal chemistry, but their synthesis is challenging. Here, the authors report a copper-catalyzed radical relay approach for the carbodifluoromethylation of alkenes that simultaneously introduces CF2H groups and complex alky...

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Autores principales:	Aijie Cai, Wenhao Yan, Xiaojun Zeng, Samson B. Zacate, Tzu-Hsuan Chao, Jeanette A. Krause, Mu-Jeng Cheng, Wei Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2631e74ef56744c9b19881e8824bf0a4
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spelling	oai:doaj.org-article:2631e74ef56744c9b19881e8824bf0a42021-12-02T18:24:58ZCopper-catalyzed carbo-difluoromethylation of alkenes via radical relay10.1038/s41467-021-23590-22041-1723https://doaj.org/article/2631e74ef56744c9b19881e8824bf0a42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23590-2https://doaj.org/toc/2041-1723Compounds that contain alkyl-difluoromethyl moieties are of interest for medicinal chemistry, but their synthesis is challenging. Here, the authors report a copper-catalyzed radical relay approach for the carbodifluoromethylation of alkenes that simultaneously introduces CF2H groups and complex alkyl or aryl groups into alkenes.Aijie CaiWenhao YanXiaojun ZengSamson B. ZacateTzu-Hsuan ChaoJeanette A. KrauseMu-Jeng ChengWei LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aijie Cai Wenhao Yan Xiaojun Zeng Samson B. Zacate Tzu-Hsuan Chao Jeanette A. Krause Mu-Jeng Cheng Wei Liu Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay
description	Compounds that contain alkyl-difluoromethyl moieties are of interest for medicinal chemistry, but their synthesis is challenging. Here, the authors report a copper-catalyzed radical relay approach for the carbodifluoromethylation of alkenes that simultaneously introduces CF2H groups and complex alkyl or aryl groups into alkenes.
format	article
author	Aijie Cai Wenhao Yan Xiaojun Zeng Samson B. Zacate Tzu-Hsuan Chao Jeanette A. Krause Mu-Jeng Cheng Wei Liu
author_facet	Aijie Cai Wenhao Yan Xiaojun Zeng Samson B. Zacate Tzu-Hsuan Chao Jeanette A. Krause Mu-Jeng Cheng Wei Liu
author_sort	Aijie Cai
title	Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay
title_short	Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay
title_full	Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay
title_fullStr	Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay
title_full_unstemmed	Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay
title_sort	copper-catalyzed carbo-difluoromethylation of alkenes via radical relay
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2631e74ef56744c9b19881e8824bf0a4
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Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay

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