Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

Abstract This study investigated neurologic changes in patients with dry eye (DE) by functional magnetic resonance imaging (fMRI) and to used regional homogeneity (ReHo) analysis to clarify the relationship between these changes and clinical features of DE. A total of 28 patients with DE and 28 matc...

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Autores principales:	Kang Yu, Yu Guo, Qian-Ming Ge, Ting Su, Wen-Qing Shi, Li-Juan Zhang, Hui-Ye Shu, Yi-Cong Pan, Rong-Bin Liang, Qiu-Yu Li, Yi Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/263384fa94364935a4e9a604f938374c
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spelling	oai:doaj.org-article:263384fa94364935a4e9a604f938374c2021-12-02T18:02:54ZAltered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study10.1038/s41598-021-92199-82045-2322https://doaj.org/article/263384fa94364935a4e9a604f938374c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92199-8https://doaj.org/toc/2045-2322Abstract This study investigated neurologic changes in patients with dry eye (DE) by functional magnetic resonance imaging (fMRI) and to used regional homogeneity (ReHo) analysis to clarify the relationship between these changes and clinical features of DE. A total of 28 patients with DE and 28 matched healthy control (HC) subjects (10 males and 18 females in each group) were enrolled. fMRI scans were performed in both groups. We carried out ReHo analysis to assess differences in neural activity between the 2 groups, and receiver operating characteristic curve (ROC) analysis was performed to evaluate the performance of ReHo values of specific brain areas in distinguishing DE patients from HCs. The relationship between average ReHo values and clinical characteristics was assessed by correlation analysis. ReHo values of the middle frontal gyrus, inferior frontal gyrus, and superior frontal gyrus were significantly lower in DE patients compared to HCs. The ROC analysis showed that ReHo value had high accuracy in distinguishing between DE patients and HCs (P < 0.0001). The ReHo values of the middle frontal gyrus and dorsolateral superior frontal gyrus were correlated to disease duration (P < 0.05). Symptoms of ocular surface injury in DE patients are associated with dysfunction in specific brain regions, which may underlie the cognitive impairment, psychiatric symptoms, and depressive mood observed in DE patients. The decreased ReHo values of some brain gyri in this study may provide a reference for clinical diagnosis and determination of treatment efficacy.Kang YuYu GuoQian-Ming GeTing SuWen-Qing ShiLi-Juan ZhangHui-Ye ShuYi-Cong PanRong-Bin LiangQiu-Yu LiYi ShaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kang Yu Yu Guo Qian-Ming Ge Ting Su Wen-Qing Shi Li-Juan Zhang Hui-Ye Shu Yi-Cong Pan Rong-Bin Liang Qiu-Yu Li Yi Shao Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study
description	Abstract This study investigated neurologic changes in patients with dry eye (DE) by functional magnetic resonance imaging (fMRI) and to used regional homogeneity (ReHo) analysis to clarify the relationship between these changes and clinical features of DE. A total of 28 patients with DE and 28 matched healthy control (HC) subjects (10 males and 18 females in each group) were enrolled. fMRI scans were performed in both groups. We carried out ReHo analysis to assess differences in neural activity between the 2 groups, and receiver operating characteristic curve (ROC) analysis was performed to evaluate the performance of ReHo values of specific brain areas in distinguishing DE patients from HCs. The relationship between average ReHo values and clinical characteristics was assessed by correlation analysis. ReHo values of the middle frontal gyrus, inferior frontal gyrus, and superior frontal gyrus were significantly lower in DE patients compared to HCs. The ROC analysis showed that ReHo value had high accuracy in distinguishing between DE patients and HCs (P < 0.0001). The ReHo values of the middle frontal gyrus and dorsolateral superior frontal gyrus were correlated to disease duration (P < 0.05). Symptoms of ocular surface injury in DE patients are associated with dysfunction in specific brain regions, which may underlie the cognitive impairment, psychiatric symptoms, and depressive mood observed in DE patients. The decreased ReHo values of some brain gyri in this study may provide a reference for clinical diagnosis and determination of treatment efficacy.
format	article
author	Kang Yu Yu Guo Qian-Ming Ge Ting Su Wen-Qing Shi Li-Juan Zhang Hui-Ye Shu Yi-Cong Pan Rong-Bin Liang Qiu-Yu Li Yi Shao
author_facet	Kang Yu Yu Guo Qian-Ming Ge Ting Su Wen-Qing Shi Li-Juan Zhang Hui-Ye Shu Yi-Cong Pan Rong-Bin Liang Qiu-Yu Li Yi Shao
author_sort	Kang Yu
title	Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study
title_short	Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study
title_full	Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study
title_fullStr	Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study
title_full_unstemmed	Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study
title_sort	altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional mri study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/263384fa94364935a4e9a604f938374c
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Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

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