Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety

Abstract Obesity remains prevalent in the US. One potential treatment is vagus nerve stimulation (VNS), which activates the sensory afferents innervating the stomach that convey stomach volume and establish satiety. However, current VNS approaches and stimulus optimization could benefit from additio...

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Autores principales:	Hailley Loper, Monique Leinen, Logan Bassoff, Jack Sample, Mario Romero-Ortega, Kenneth J. Gustafson, Dawn M. Taylor, Matthew A. Schiefer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2639f6d0bdc84cea9b32126f8ced26bd
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spelling	oai:doaj.org-article:2639f6d0bdc84cea9b32126f8ced26bd2021-12-02T14:58:53ZBoth high fat and high carbohydrate diets impair vagus nerve signaling of satiety10.1038/s41598-021-89465-02045-2322https://doaj.org/article/2639f6d0bdc84cea9b32126f8ced26bd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89465-0https://doaj.org/toc/2045-2322Abstract Obesity remains prevalent in the US. One potential treatment is vagus nerve stimulation (VNS), which activates the sensory afferents innervating the stomach that convey stomach volume and establish satiety. However, current VNS approaches and stimulus optimization could benefit from additional understanding of the underlying neural response to stomach distension. In this study, obesity-prone Sprague Dawley rats consumed a standard, high-carbohydrate, or high-fat diet for several months, leading to diet-induced obesity in the latter two groups. Under anesthesia, the neural activity in the vagus nerve was recorded with a penetrating microelectrode array while the stomach was distended with an implanted balloon. Vagal tone during distension was compared to baseline tone prior to distension. Responses were strongly correlated with stomach distension, but the sensitivity to distension was significantly lower in animals that had been fed the nonstandard diets. The results indicate that both high fat and high carbohydrate diets impair vagus activity.Hailley LoperMonique LeinenLogan BassoffJack SampleMario Romero-OrtegaKenneth J. GustafsonDawn M. TaylorMatthew A. SchieferNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hailley Loper Monique Leinen Logan Bassoff Jack Sample Mario Romero-Ortega Kenneth J. Gustafson Dawn M. Taylor Matthew A. Schiefer Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety
description	Abstract Obesity remains prevalent in the US. One potential treatment is vagus nerve stimulation (VNS), which activates the sensory afferents innervating the stomach that convey stomach volume and establish satiety. However, current VNS approaches and stimulus optimization could benefit from additional understanding of the underlying neural response to stomach distension. In this study, obesity-prone Sprague Dawley rats consumed a standard, high-carbohydrate, or high-fat diet for several months, leading to diet-induced obesity in the latter two groups. Under anesthesia, the neural activity in the vagus nerve was recorded with a penetrating microelectrode array while the stomach was distended with an implanted balloon. Vagal tone during distension was compared to baseline tone prior to distension. Responses were strongly correlated with stomach distension, but the sensitivity to distension was significantly lower in animals that had been fed the nonstandard diets. The results indicate that both high fat and high carbohydrate diets impair vagus activity.
format	article
author	Hailley Loper Monique Leinen Logan Bassoff Jack Sample Mario Romero-Ortega Kenneth J. Gustafson Dawn M. Taylor Matthew A. Schiefer
author_facet	Hailley Loper Monique Leinen Logan Bassoff Jack Sample Mario Romero-Ortega Kenneth J. Gustafson Dawn M. Taylor Matthew A. Schiefer
author_sort	Hailley Loper
title	Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety
title_short	Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety
title_full	Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety
title_fullStr	Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety
title_full_unstemmed	Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety
title_sort	both high fat and high carbohydrate diets impair vagus nerve signaling of satiety
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2639f6d0bdc84cea9b32126f8ced26bd
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Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety

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