Breath and plasma metabolomics to assess inflammation in acute stroke

Abstract Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic analysis of plasma collected at multiple t...

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Autores principales:	Waqar Ahmed, Iain R. White, Maxim Wilkinson, Craig F. Johnson, Nicholas Rattray, Amit K. Kishore, Royston Goodacre, Craig J. Smith, Stephen J. Fowler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/263bc1bb366f407493f151fb380588c1
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spelling	oai:doaj.org-article:263bc1bb366f407493f151fb380588c12021-11-14T12:19:18ZBreath and plasma metabolomics to assess inflammation in acute stroke10.1038/s41598-021-01268-52045-2322https://doaj.org/article/263bc1bb366f407493f151fb380588c12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01268-5https://doaj.org/toc/2045-2322Abstract Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic analysis of plasma collected at multiple time periods after stroke. Metabolic profiles were compared with the time course of the inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). Serial breath sampling was well-tolerated by all patients and the measurement appears feasible in this group. We found that exhaled decanal tracks CRP and IL-6 levels post-stroke and correlates with several metabolic pathways associated with a post-stroke inflammatory response. This suggests that measurement of breath and blood metabolites could facilitate development of novel therapeutic and diagnostic strategies. Results are discussed in relation to the utility of breath analysis in stroke care, such as in monitoring recovery and complications including stroke associated infection.Waqar AhmedIain R. WhiteMaxim WilkinsonCraig F. JohnsonNicholas RattrayAmit K. KishoreRoyston GoodacreCraig J. SmithStephen J. FowlerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Waqar Ahmed Iain R. White Maxim Wilkinson Craig F. Johnson Nicholas Rattray Amit K. Kishore Royston Goodacre Craig J. Smith Stephen J. Fowler Breath and plasma metabolomics to assess inflammation in acute stroke
description	Abstract Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic analysis of plasma collected at multiple time periods after stroke. Metabolic profiles were compared with the time course of the inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). Serial breath sampling was well-tolerated by all patients and the measurement appears feasible in this group. We found that exhaled decanal tracks CRP and IL-6 levels post-stroke and correlates with several metabolic pathways associated with a post-stroke inflammatory response. This suggests that measurement of breath and blood metabolites could facilitate development of novel therapeutic and diagnostic strategies. Results are discussed in relation to the utility of breath analysis in stroke care, such as in monitoring recovery and complications including stroke associated infection.
format	article
author	Waqar Ahmed Iain R. White Maxim Wilkinson Craig F. Johnson Nicholas Rattray Amit K. Kishore Royston Goodacre Craig J. Smith Stephen J. Fowler
author_facet	Waqar Ahmed Iain R. White Maxim Wilkinson Craig F. Johnson Nicholas Rattray Amit K. Kishore Royston Goodacre Craig J. Smith Stephen J. Fowler
author_sort	Waqar Ahmed
title	Breath and plasma metabolomics to assess inflammation in acute stroke
title_short	Breath and plasma metabolomics to assess inflammation in acute stroke
title_full	Breath and plasma metabolomics to assess inflammation in acute stroke
title_fullStr	Breath and plasma metabolomics to assess inflammation in acute stroke
title_full_unstemmed	Breath and plasma metabolomics to assess inflammation in acute stroke
title_sort	breath and plasma metabolomics to assess inflammation in acute stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/263bc1bb366f407493f151fb380588c1
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Breath and plasma metabolomics to assess inflammation in acute stroke

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