Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis <italic toggle="yes">In Vivo</italic>

Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis <italic toggle="yes">In Vivo</italic>

ABSTRACT Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogenesis in vivo remain unclear. Here, we evaluated th...

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Autores principales: Andrew S. Herbert, Cristin Davidson, Ana I. Kuehne, Russell Bakken, Stephen Z. Braigen, Kathryn E. Gunn, Sean P. Whelan, Thijn R. Brummelkamp, Nancy A. Twenhafel, Kartik Chandran, Steven U. Walkley, John M. Dye
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/263ccfc6711f4321bc9f6e259ae2e4fb
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https://doaj.org/article/263ccfc6711f4321bc9f6e259ae2e4fb

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