Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis <italic toggle="yes">In Vivo</italic>

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Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis <italic toggle="yes">In Vivo</italic>

ABSTRACT Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogenesis in vivo remain unclear. Here, we evaluated th...

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Auteurs principaux:	Andrew S. Herbert, Cristin Davidson, Ana I. Kuehne, Russell Bakken, Stephen Z. Braigen, Kathryn E. Gunn, Sean P. Whelan, Thijn R. Brummelkamp, Nancy A. Twenhafel, Kartik Chandran, Steven U. Walkley, John M. Dye
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2015
Sujets:	Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/263ccfc6711f4321bc9f6e259ae2e4fb
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