Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis

Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis

How enhancers transition from a hypoacetylated primed state to a hyperacetylated-active state in response to differentiation stimuli is incompletely understood. Here the authors show that SETD5 forms a complex with NCoR-HDAC3 co-repressor to prevent histone acetylation of master adipogenic gene enha...

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Autores principales: Yoshihiro Matsumura, Ryo Ito, Ayumu Yajima, Rei Yamaguchi, Toshiya Tanaka, Takeshi Kawamura, Kenta Magoori, Yohei Abe, Aoi Uchida, Takeshi Yoneshiro, Hiroyuki Hirakawa, Ji Zhang, Makoto Arai, Chaoran Yang, Ge Yang, Hiroki Takahashi, Hitomi Fujihashi, Ryo Nakaki, Shogo Yamamoto, Satoshi Ota, Shuichi Tsutsumi, Shin-ichi Inoue, Hiroshi Kimura, Youichiro Wada, Tatsuhiko Kodama, Takeshi Inagaki, Timothy F. Osborne, Hiroyuki Aburatani, Koichi Node, Juro Sakai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2640437aeaa849649cfb58cee545c8e6
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spelling oai:doaj.org-article:2640437aeaa849649cfb58cee545c8e62021-12-05T12:22:01ZSpatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis10.1038/s41467-021-27321-52041-1723https://doaj.org/article/2640437aeaa849649cfb58cee545c8e62021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27321-5https://doaj.org/toc/2041-1723How enhancers transition from a hypoacetylated primed state to a hyperacetylated-active state in response to differentiation stimuli is incompletely understood. Here the authors show that SETD5 forms a complex with NCoR-HDAC3 co-repressor to prevent histone acetylation of master adipogenic gene enhancers, while SETD5 degradation triggers enhancer hyperacetylation and transition to active state.Yoshihiro MatsumuraRyo ItoAyumu YajimaRei YamaguchiToshiya TanakaTakeshi KawamuraKenta MagooriYohei AbeAoi UchidaTakeshi YoneshiroHiroyuki HirakawaJi ZhangMakoto AraiChaoran YangGe YangHiroki TakahashiHitomi FujihashiRyo NakakiShogo YamamotoSatoshi OtaShuichi TsutsumiShin-ichi InoueHiroshi KimuraYouichiro WadaTatsuhiko KodamaTakeshi InagakiTimothy F. OsborneHiroyuki AburataniKoichi NodeJuro SakaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yoshihiro Matsumura
Ryo Ito
Ayumu Yajima
Rei Yamaguchi
Toshiya Tanaka
Takeshi Kawamura
Kenta Magoori
Yohei Abe
Aoi Uchida
Takeshi Yoneshiro
Hiroyuki Hirakawa
Ji Zhang
Makoto Arai
Chaoran Yang
Ge Yang
Hiroki Takahashi
Hitomi Fujihashi
Ryo Nakaki
Shogo Yamamoto
Satoshi Ota
Shuichi Tsutsumi
Shin-ichi Inoue
Hiroshi Kimura
Youichiro Wada
Tatsuhiko Kodama
Takeshi Inagaki
Timothy F. Osborne
Hiroyuki Aburatani
Koichi Node
Juro Sakai
Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
description How enhancers transition from a hypoacetylated primed state to a hyperacetylated-active state in response to differentiation stimuli is incompletely understood. Here the authors show that SETD5 forms a complex with NCoR-HDAC3 co-repressor to prevent histone acetylation of master adipogenic gene enhancers, while SETD5 degradation triggers enhancer hyperacetylation and transition to active state.
format article
author Yoshihiro Matsumura
Ryo Ito
Ayumu Yajima
Rei Yamaguchi
Toshiya Tanaka
Takeshi Kawamura
Kenta Magoori
Yohei Abe
Aoi Uchida
Takeshi Yoneshiro
Hiroyuki Hirakawa
Ji Zhang
Makoto Arai
Chaoran Yang
Ge Yang
Hiroki Takahashi
Hitomi Fujihashi
Ryo Nakaki
Shogo Yamamoto
Satoshi Ota
Shuichi Tsutsumi
Shin-ichi Inoue
Hiroshi Kimura
Youichiro Wada
Tatsuhiko Kodama
Takeshi Inagaki
Timothy F. Osborne
Hiroyuki Aburatani
Koichi Node
Juro Sakai
author_facet Yoshihiro Matsumura
Ryo Ito
Ayumu Yajima
Rei Yamaguchi
Toshiya Tanaka
Takeshi Kawamura
Kenta Magoori
Yohei Abe
Aoi Uchida
Takeshi Yoneshiro
Hiroyuki Hirakawa
Ji Zhang
Makoto Arai
Chaoran Yang
Ge Yang
Hiroki Takahashi
Hitomi Fujihashi
Ryo Nakaki
Shogo Yamamoto
Satoshi Ota
Shuichi Tsutsumi
Shin-ichi Inoue
Hiroshi Kimura
Youichiro Wada
Tatsuhiko Kodama
Takeshi Inagaki
Timothy F. Osborne
Hiroyuki Aburatani
Koichi Node
Juro Sakai
author_sort Yoshihiro Matsumura
title Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
title_short Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
title_full Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
title_fullStr Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
title_full_unstemmed Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
title_sort spatiotemporal dynamics of setd5-containing ncor–hdac3 complex determines enhancer activation for adipogenesis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2640437aeaa849649cfb58cee545c8e6
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