Host-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies

ABSTRACT Despite growing efforts to understand the role of the microbiota in airway disease, mechanisms that link microbial community dysbiosis to chronic inflammation remain elusive. Our laboratory is interested in how altered microbiota composition or function influences airway inflammatory diseas...

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Autor principal:	Emily K. Cope
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	airway microbiome asthma chronic rhinosinusitis host-microbiome interaction microbial therapeutics probiotics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/26483d48d35c459cb774927e3151d5a8
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spelling	oai:doaj.org-article:26483d48d35c459cb774927e3151d5a82021-12-02T19:47:34ZHost-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies10.1128/mSystems.00158-172379-5077https://doaj.org/article/26483d48d35c459cb774927e3151d5a82018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00158-17https://doaj.org/toc/2379-5077ABSTRACT Despite growing efforts to understand the role of the microbiota in airway disease, mechanisms that link microbial community dysbiosis to chronic inflammation remain elusive. Our laboratory is interested in how altered microbiota composition or function influences airway inflammatory diseases, including chronic rhinosinusitis, asthma, and cystic fibrosis. Given the tight interplay between host-associated microbes and host immunity, the potential for translational microbiome research to guide clinical decisions and novel therapeutics is becoming better appreciated. We hope to advance our understanding of the ecology of airway disease through integrating multiple omics assays and in vitro and in vivo experimental validation. An increased understanding of the role of the microbiota in chronic airway inflammation will ultimately lead to the rational development of therapeutics aimed at manipulation of microbiota composition or activity to treat these important and costly diseases. In this perspective, I discuss our current research investigating the microbiology and ecology of the airway microbiome.Emily K. CopeAmerican Society for Microbiologyarticleairway microbiomeasthmachronic rhinosinusitishost-microbiome interactionmicrobial therapeuticsprobioticsMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	airway microbiome asthma chronic rhinosinusitis host-microbiome interaction microbial therapeutics probiotics Microbiology QR1-502
spellingShingle	airway microbiome asthma chronic rhinosinusitis host-microbiome interaction microbial therapeutics probiotics Microbiology QR1-502 Emily K. Cope Host-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies
description	ABSTRACT Despite growing efforts to understand the role of the microbiota in airway disease, mechanisms that link microbial community dysbiosis to chronic inflammation remain elusive. Our laboratory is interested in how altered microbiota composition or function influences airway inflammatory diseases, including chronic rhinosinusitis, asthma, and cystic fibrosis. Given the tight interplay between host-associated microbes and host immunity, the potential for translational microbiome research to guide clinical decisions and novel therapeutics is becoming better appreciated. We hope to advance our understanding of the ecology of airway disease through integrating multiple omics assays and in vitro and in vivo experimental validation. An increased understanding of the role of the microbiota in chronic airway inflammation will ultimately lead to the rational development of therapeutics aimed at manipulation of microbiota composition or activity to treat these important and costly diseases. In this perspective, I discuss our current research investigating the microbiology and ecology of the airway microbiome.
format	article
author	Emily K. Cope
author_facet	Emily K. Cope
author_sort	Emily K. Cope
title	Host-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies
title_short	Host-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies
title_full	Host-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies
title_fullStr	Host-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies
title_full_unstemmed	Host-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies
title_sort	host-microbe interactions in airway disease: toward disease mechanisms and novel therapeutic strategies
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/26483d48d35c459cb774927e3151d5a8
work_keys_str_mv	AT emilykcope hostmicrobeinteractionsinairwaydiseasetowarddiseasemechanismsandnoveltherapeuticstrategies
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Host-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies

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