Network-based approach to prediction and population-based validation of in silico drug repurposing

Repurposing approved drugs could accelerate treatment options for various diseases. Here, the authors use network proximity of disease gene products and drug targets in the human protein interactome to identify drug-disease associations for cardiovascular disease, and validate these using longitudin...

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Autores principales: Feixiong Cheng, Rishi J. Desai, Diane E. Handy, Ruisheng Wang, Sebastian Schneeweiss, Albert-László Barabási, Joseph Loscalzo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/264d3bc2952944739e5a0650a3d519eb
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Sumario:Repurposing approved drugs could accelerate treatment options for various diseases. Here, the authors use network proximity of disease gene products and drug targets in the human protein interactome to identify drug-disease associations for cardiovascular disease, and validate these using longitudinal healthcare data.