Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro

Oleanolic acid (OA) is a pentacyclic triterpenoid, abundantly found in plants of the <i>Oleaceae</i> family, and is well known for its beneficial pharmacological activities. Previously, we reported the inhibitory effect of OA on mast cell-mediated allergic inflammation. In this study, we...

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Autores principales:	Yun-Mi Kang, Hye-Min Kim, Minho Lee, Hyo-Jin An
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oleanolic acid atopic dermatitis 2,4-dinitrochlorobenzene keratinocyte NF-κB STAT1 Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/264d7006c45c45f6805bc74fe7212255
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spelling	oai:doaj.org-article:264d7006c45c45f6805bc74fe72122552021-11-11T17:24:59ZOleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro10.3390/ijms2221120001422-00671661-6596https://doaj.org/article/264d7006c45c45f6805bc74fe72122552021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12000https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Oleanolic acid (OA) is a pentacyclic triterpenoid, abundantly found in plants of the <i>Oleaceae</i> family, and is well known for its beneficial pharmacological activities. Previously, we reported the inhibitory effect of OA on mast cell-mediated allergic inflammation. In this study, we investigated the effects of OA on atopic dermatitis (AD)-like skin lesions and its underlying mechanism of action. We evaluated the inhibitory effect of OA on AD-like responses and the possible mechanisms using a 1-chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD animal model and tumor necrosis factor (TNF)-α/interferon (IFN)-γ-stimulated HaCaT keratinocytes. We found that OA has anti-atopic effects, including histological alterations, on DNCB-induced AD-like lesions in mice. Moreover, it suppressed the expression of Th2 type cytokines and chemokines in the AD mouse model and TNF-α/IFN-γ-induced HaCaT keratinocytes by blocking the activation of serine-threonine kinase Akt, nuclear factor-κB, and the signal transducer and activator of transcription 1. The results demonstrate that OA inhibits AD-like symptoms and regulates the inflammatory mediators; therefore, it may be used as an effective and attractive therapeutic agent for allergic disorders, such as AD. Moreover, the findings of this study provide novel insights into the potential pharmacological targets of OA for treating AD.Yun-Mi KangHye-Min KimMinho LeeHyo-Jin AnMDPI AGarticleoleanolic acidatopic dermatitis2,4-dinitrochlorobenzenekeratinocyteNF-κBSTAT1Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12000, p 12000 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oleanolic acid atopic dermatitis 2,4-dinitrochlorobenzene keratinocyte NF-κB STAT1 Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	oleanolic acid atopic dermatitis 2,4-dinitrochlorobenzene keratinocyte NF-κB STAT1 Biology (General) QH301-705.5 Chemistry QD1-999 Yun-Mi Kang Hye-Min Kim Minho Lee Hyo-Jin An Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro
description	Oleanolic acid (OA) is a pentacyclic triterpenoid, abundantly found in plants of the <i>Oleaceae</i> family, and is well known for its beneficial pharmacological activities. Previously, we reported the inhibitory effect of OA on mast cell-mediated allergic inflammation. In this study, we investigated the effects of OA on atopic dermatitis (AD)-like skin lesions and its underlying mechanism of action. We evaluated the inhibitory effect of OA on AD-like responses and the possible mechanisms using a 1-chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD animal model and tumor necrosis factor (TNF)-α/interferon (IFN)-γ-stimulated HaCaT keratinocytes. We found that OA has anti-atopic effects, including histological alterations, on DNCB-induced AD-like lesions in mice. Moreover, it suppressed the expression of Th2 type cytokines and chemokines in the AD mouse model and TNF-α/IFN-γ-induced HaCaT keratinocytes by blocking the activation of serine-threonine kinase Akt, nuclear factor-κB, and the signal transducer and activator of transcription 1. The results demonstrate that OA inhibits AD-like symptoms and regulates the inflammatory mediators; therefore, it may be used as an effective and attractive therapeutic agent for allergic disorders, such as AD. Moreover, the findings of this study provide novel insights into the potential pharmacological targets of OA for treating AD.
format	article
author	Yun-Mi Kang Hye-Min Kim Minho Lee Hyo-Jin An
author_facet	Yun-Mi Kang Hye-Min Kim Minho Lee Hyo-Jin An
author_sort	Yun-Mi Kang
title	Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro
title_short	Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro
title_full	Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro
title_fullStr	Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro
title_full_unstemmed	Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro
title_sort	oleanolic acid alleviates atopic dermatitis-like responses in vivo and in vitro
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/264d7006c45c45f6805bc74fe7212255
work_keys_str_mv	AT yunmikang oleanolicacidalleviatesatopicdermatitislikeresponsesinvivoandinvitro AT hyeminkim oleanolicacidalleviatesatopicdermatitislikeresponsesinvivoandinvitro AT minholee oleanolicacidalleviatesatopicdermatitislikeresponsesinvivoandinvitro AT hyojinan oleanolicacidalleviatesatopicdermatitislikeresponsesinvivoandinvitro
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Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro

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