Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy

A number of therapeutic agents aimed at reducing pathology in Duchenne muscular dystrophy have been developed, but may have off-target effects when delivered systemically. Here, the authors express the therapeutic LIF transgene in leukocytes, and show this results in targeting to inflamed dystrophic...

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Autores principales:	Steven S. Welc, Ivan Flores, Michelle Wehling-Henricks, Julian Ramos, Ying Wang, Carmen Bertoni, James G. Tidball
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/264ed254b4494b4a8400489886319488
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spelling	oai:doaj.org-article:264ed254b4494b4a84004898863194882021-12-02T17:01:32ZTargeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy10.1038/s41467-019-10614-12041-1723https://doaj.org/article/264ed254b4494b4a84004898863194882019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10614-1https://doaj.org/toc/2041-1723A number of therapeutic agents aimed at reducing pathology in Duchenne muscular dystrophy have been developed, but may have off-target effects when delivered systemically. Here, the authors express the therapeutic LIF transgene in leukocytes, and show this results in targeting to inflamed dystrophic muscle and reduced fibrosis by suppressing type 2 immunity.Steven S. WelcIvan FloresMichelle Wehling-HenricksJulian RamosYing WangCarmen BertoniJames G. TidballNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Steven S. Welc Ivan Flores Michelle Wehling-Henricks Julian Ramos Ying Wang Carmen Bertoni James G. Tidball Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
description	A number of therapeutic agents aimed at reducing pathology in Duchenne muscular dystrophy have been developed, but may have off-target effects when delivered systemically. Here, the authors express the therapeutic LIF transgene in leukocytes, and show this results in targeting to inflamed dystrophic muscle and reduced fibrosis by suppressing type 2 immunity.
format	article
author	Steven S. Welc Ivan Flores Michelle Wehling-Henricks Julian Ramos Ying Wang Carmen Bertoni James G. Tidball
author_facet	Steven S. Welc Ivan Flores Michelle Wehling-Henricks Julian Ramos Ying Wang Carmen Bertoni James G. Tidball
author_sort	Steven S. Welc
title	Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
title_short	Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
title_full	Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
title_fullStr	Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
title_full_unstemmed	Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
title_sort	targeting a therapeutic lif transgene to muscle via the immune system ameliorates muscular dystrophy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/264ed254b4494b4a8400489886319488
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Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy

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