GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats

Abstract This study investigated the role of GABA in attenuating liver insulin resistance (IR) in type 2 diabetes parents and reducing its risk in their descendants’ liver. Both sexes’ rats were divided into four groups of non-diabetic control, diabetic control (DC), GABA-treated (GABA), and insulin...

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Autores principales:	Azadehalsadat Hosseini Dastgerdi, Mohammadreza Sharifi, Nepton Soltani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2654ea711c034e70a681731a750ccab8
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spelling	oai:doaj.org-article:2654ea711c034e70a681731a750ccab82021-12-05T12:11:26ZGABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats10.1038/s41598-021-02324-w2045-2322https://doaj.org/article/2654ea711c034e70a681731a750ccab82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02324-whttps://doaj.org/toc/2045-2322Abstract This study investigated the role of GABA in attenuating liver insulin resistance (IR) in type 2 diabetes parents and reducing its risk in their descendants’ liver. Both sexes’ rats were divided into four groups of non-diabetic control, diabetic control (DC), GABA-treated (GABA), and insulin-treated (Ins). The study duration lasted for six months and the young animals followed for four months. Consequently, hyperinsulinemic-euglycemic clamp was performed for all animals. Apart from insulin tolerance test (ITT), serum and liver lipid profile were measured in all groups. Glycogen levels, expression of Foxo1, Irs2, Akt2, and Pepck genes in the liver were assessed for all groups. Overall, GABA improved ITT, increased liver glycogen levels and decreased lipid profile, blood glucose level, and HbA1c in parents and their offspring in compared to the DC group. GIR also increased in both parents and their offspring by GABA. Moreover, the expression of Foxo1, Irs2, Akt2, and Pepck genes improved in GABA-treated parents and their descendants in compared to DC group. Results indicated that GABA reduced liver IR in both parents and their offspring via affecting their liver insulin signaling and gluconeogenesis pathways.Azadehalsadat Hosseini DastgerdiMohammadreza SharifiNepton SoltaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Azadehalsadat Hosseini Dastgerdi Mohammadreza Sharifi Nepton Soltani GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats
description	Abstract This study investigated the role of GABA in attenuating liver insulin resistance (IR) in type 2 diabetes parents and reducing its risk in their descendants’ liver. Both sexes’ rats were divided into four groups of non-diabetic control, diabetic control (DC), GABA-treated (GABA), and insulin-treated (Ins). The study duration lasted for six months and the young animals followed for four months. Consequently, hyperinsulinemic-euglycemic clamp was performed for all animals. Apart from insulin tolerance test (ITT), serum and liver lipid profile were measured in all groups. Glycogen levels, expression of Foxo1, Irs2, Akt2, and Pepck genes in the liver were assessed for all groups. Overall, GABA improved ITT, increased liver glycogen levels and decreased lipid profile, blood glucose level, and HbA1c in parents and their offspring in compared to the DC group. GIR also increased in both parents and their offspring by GABA. Moreover, the expression of Foxo1, Irs2, Akt2, and Pepck genes improved in GABA-treated parents and their descendants in compared to DC group. Results indicated that GABA reduced liver IR in both parents and their offspring via affecting their liver insulin signaling and gluconeogenesis pathways.
format	article
author	Azadehalsadat Hosseini Dastgerdi Mohammadreza Sharifi Nepton Soltani
author_facet	Azadehalsadat Hosseini Dastgerdi Mohammadreza Sharifi Nepton Soltani
author_sort	Azadehalsadat Hosseini Dastgerdi
title	GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats
title_short	GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats
title_full	GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats
title_fullStr	GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats
title_full_unstemmed	GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats
title_sort	gaba administration improves liver function and insulin resistance in offspring of type 2 diabetic rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2654ea711c034e70a681731a750ccab8
work_keys_str_mv	AT azadehalsadathosseinidastgerdi gabaadministrationimprovesliverfunctionandinsulinresistanceinoffspringoftype2diabeticrats AT mohammadrezasharifi gabaadministrationimprovesliverfunctionandinsulinresistanceinoffspringoftype2diabeticrats AT neptonsoltani gabaadministrationimprovesliverfunctionandinsulinresistanceinoffspringoftype2diabeticrats
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GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats

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