RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

A nucleotide repeat expansion in C9orf72 is a common genetic cause of neurodegenerative disorders. Here, the authors provide insight into the molecular mechanism by which this repeat undergoes Repeat-Associated Non-AUG (RAN) translation, implicating the integrated stress response and eIF2α phosphory...

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Autores principales:	Katelyn M. Green, M. Rebecca Glineburg, Michael G. Kearse, Brittany N. Flores, Alexander E. Linsalata, Stephen J. Fedak, Aaron C. Goldstrohm, Sami J. Barmada, Peter K. Todd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/265548349b414438ad9f9384c10a2220
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spelling	oai:doaj.org-article:265548349b414438ad9f9384c10a22202021-12-02T14:42:23ZRAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response10.1038/s41467-017-02200-02041-1723https://doaj.org/article/265548349b414438ad9f9384c10a22202017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02200-0https://doaj.org/toc/2041-1723A nucleotide repeat expansion in C9orf72 is a common genetic cause of neurodegenerative disorders. Here, the authors provide insight into the molecular mechanism by which this repeat undergoes Repeat-Associated Non-AUG (RAN) translation, implicating the integrated stress response and eIF2α phosphorylation.Katelyn M. GreenM. Rebecca GlineburgMichael G. KearseBrittany N. FloresAlexander E. LinsalataStephen J. FedakAaron C. GoldstrohmSami J. BarmadaPeter K. ToddNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katelyn M. Green M. Rebecca Glineburg Michael G. Kearse Brittany N. Flores Alexander E. Linsalata Stephen J. Fedak Aaron C. Goldstrohm Sami J. Barmada Peter K. Todd RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response
description	A nucleotide repeat expansion in C9orf72 is a common genetic cause of neurodegenerative disorders. Here, the authors provide insight into the molecular mechanism by which this repeat undergoes Repeat-Associated Non-AUG (RAN) translation, implicating the integrated stress response and eIF2α phosphorylation.
format	article
author	Katelyn M. Green M. Rebecca Glineburg Michael G. Kearse Brittany N. Flores Alexander E. Linsalata Stephen J. Fedak Aaron C. Goldstrohm Sami J. Barmada Peter K. Todd
author_facet	Katelyn M. Green M. Rebecca Glineburg Michael G. Kearse Brittany N. Flores Alexander E. Linsalata Stephen J. Fedak Aaron C. Goldstrohm Sami J. Barmada Peter K. Todd
author_sort	Katelyn M. Green
title	RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response
title_short	RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response
title_full	RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response
title_fullStr	RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response
title_full_unstemmed	RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response
title_sort	ran translation at c9orf72-associated repeat expansions is selectively enhanced by the integrated stress response
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/265548349b414438ad9f9384c10a2220
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RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

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