Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis

Katja Schlatterer et al. use mouse models to show that elevated serum acetate concentrations prime human neutrophils in a GPR43-dependent fashion, and rescue mice from severe sepsis. These results suggest microbiome-, diet-, or pathogen-derived short-chain fatty acids govern the defense capacities o...

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Autores principales:	Katja Schlatterer, Christian Beck, Ulrich Schoppmeier, Andreas Peschel, Dorothee Kretschmer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/265b36b4deea45b389c648da82651a68
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spelling	oai:doaj.org-article:265b36b4deea45b389c648da82651a682021-12-02T16:06:36ZAcetate sensing by GPR43 alarms neutrophils and protects from severe sepsis10.1038/s42003-021-02427-02399-3642https://doaj.org/article/265b36b4deea45b389c648da82651a682021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02427-0https://doaj.org/toc/2399-3642Katja Schlatterer et al. use mouse models to show that elevated serum acetate concentrations prime human neutrophils in a GPR43-dependent fashion, and rescue mice from severe sepsis. These results suggest microbiome-, diet-, or pathogen-derived short-chain fatty acids govern the defense capacities of immune cells, potentially hinting at the therapeutic potential of GPR43 in treating sepsis.Katja SchlattererChristian BeckUlrich SchoppmeierAndreas PeschelDorothee KretschmerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Katja Schlatterer Christian Beck Ulrich Schoppmeier Andreas Peschel Dorothee Kretschmer Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis
description	Katja Schlatterer et al. use mouse models to show that elevated serum acetate concentrations prime human neutrophils in a GPR43-dependent fashion, and rescue mice from severe sepsis. These results suggest microbiome-, diet-, or pathogen-derived short-chain fatty acids govern the defense capacities of immune cells, potentially hinting at the therapeutic potential of GPR43 in treating sepsis.
format	article
author	Katja Schlatterer Christian Beck Ulrich Schoppmeier Andreas Peschel Dorothee Kretschmer
author_facet	Katja Schlatterer Christian Beck Ulrich Schoppmeier Andreas Peschel Dorothee Kretschmer
author_sort	Katja Schlatterer
title	Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis
title_short	Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis
title_full	Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis
title_fullStr	Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis
title_full_unstemmed	Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis
title_sort	acetate sensing by gpr43 alarms neutrophils and protects from severe sepsis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/265b36b4deea45b389c648da82651a68
work_keys_str_mv	AT katjaschlatterer acetatesensingbygpr43alarmsneutrophilsandprotectsfromseveresepsis AT christianbeck acetatesensingbygpr43alarmsneutrophilsandprotectsfromseveresepsis AT ulrichschoppmeier acetatesensingbygpr43alarmsneutrophilsandprotectsfromseveresepsis AT andreaspeschel acetatesensingbygpr43alarmsneutrophilsandprotectsfromseveresepsis AT dorotheekretschmer acetatesensingbygpr43alarmsneutrophilsandprotectsfromseveresepsis
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Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis

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