Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis
Katja Schlatterer et al. use mouse models to show that elevated serum acetate concentrations prime human neutrophils in a GPR43-dependent fashion, and rescue mice from severe sepsis. These results suggest microbiome-, diet-, or pathogen-derived short-chain fatty acids govern the defense capacities o...
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| Main Authors: | , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/265b36b4deea45b389c648da82651a68 |
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