Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males

Abstract Preclinical and clinical studies have shown that sex is a significant risk factor for perinatal morbidity and mortality, with males being more susceptible to neonatal hypoxic ischemic (HI) brain injury. No study has investigated sexual dimorphism in the efficacy of umbilical cord blood (UCB...

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Autores principales:	Tayla R. Penny, Yen Pham, Amy E. Sutherland, Joohyung Lee, Graham Jenkin, Michael C. Fahey, Suzanne L. Miller, Courtney A. McDonald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/265b40370d044d94b2afa0c170719093
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spelling	oai:doaj.org-article:265b40370d044d94b2afa0c1707190932021-12-02T18:49:21ZUmbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males10.1038/s41598-021-95035-12045-2322https://doaj.org/article/265b40370d044d94b2afa0c1707190932021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95035-1https://doaj.org/toc/2045-2322Abstract Preclinical and clinical studies have shown that sex is a significant risk factor for perinatal morbidity and mortality, with males being more susceptible to neonatal hypoxic ischemic (HI) brain injury. No study has investigated sexual dimorphism in the efficacy of umbilical cord blood (UCB) cell therapy. HI injury was induced in postnatal day 10 (PND10) rat pups using the Rice-Vannucci method of carotid artery ligation. Pups received 3 doses of UCB cells (PND11, 13, 20) and underwent behavioural testing. On PND50, brains were collected for immunohistochemical analysis. Behavioural and neuropathological outcomes were assessed for sex differences. HI brain injury resulted in a significant decrease in brain weight and increase in tissue loss in females and males. Females and males also exhibited significant cell death, region-specific neuron loss and long-term behavioural deficits. Females had significantly smaller brains overall compared to males and males had significantly reduced neuron numbers in the cortex compared to females. UCB administration improved multiple aspects of neuropathology and functional outcomes in males and females. Females and males both exhibited injury following HI. This is the first preclinical evidence that UCB is an appropriate treatment for neonatal brain injury in both female and male neonates.Tayla R. PennyYen PhamAmy E. SutherlandJoohyung LeeGraham JenkinMichael C. FaheySuzanne L. MillerCourtney A. McDonaldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tayla R. Penny Yen Pham Amy E. Sutherland Joohyung Lee Graham Jenkin Michael C. Fahey Suzanne L. Miller Courtney A. McDonald Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males
description	Abstract Preclinical and clinical studies have shown that sex is a significant risk factor for perinatal morbidity and mortality, with males being more susceptible to neonatal hypoxic ischemic (HI) brain injury. No study has investigated sexual dimorphism in the efficacy of umbilical cord blood (UCB) cell therapy. HI injury was induced in postnatal day 10 (PND10) rat pups using the Rice-Vannucci method of carotid artery ligation. Pups received 3 doses of UCB cells (PND11, 13, 20) and underwent behavioural testing. On PND50, brains were collected for immunohistochemical analysis. Behavioural and neuropathological outcomes were assessed for sex differences. HI brain injury resulted in a significant decrease in brain weight and increase in tissue loss in females and males. Females and males also exhibited significant cell death, region-specific neuron loss and long-term behavioural deficits. Females had significantly smaller brains overall compared to males and males had significantly reduced neuron numbers in the cortex compared to females. UCB administration improved multiple aspects of neuropathology and functional outcomes in males and females. Females and males both exhibited injury following HI. This is the first preclinical evidence that UCB is an appropriate treatment for neonatal brain injury in both female and male neonates.
format	article
author	Tayla R. Penny Yen Pham Amy E. Sutherland Joohyung Lee Graham Jenkin Michael C. Fahey Suzanne L. Miller Courtney A. McDonald
author_facet	Tayla R. Penny Yen Pham Amy E. Sutherland Joohyung Lee Graham Jenkin Michael C. Fahey Suzanne L. Miller Courtney A. McDonald
author_sort	Tayla R. Penny
title	Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males
title_short	Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males
title_full	Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males
title_fullStr	Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males
title_full_unstemmed	Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males
title_sort	umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/265b40370d044d94b2afa0c170719093
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Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males

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