Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults

Abstract Background Accumulating evidence shows that physical exercise has a positive effect on the release of neurotrophic factors and myokines. However, evidence regarding the optimal type of physical exercise for these release is still lacking. The aim of this study was to assess the acute and ch...

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Autores principales:	Tom Behrendt, Franziska Kirschnick, Lasse Kröger, Phillip Beileke, Maxim Rezepin, Tanja Brigadski, Volkmar Leßmann, Lutz Schega
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Open skill exercise Closed skill exercise Brain-derived neurotrophic factor (BDNF) Insulin-like growth factor 1 (IGF-1) Interleukin-6 (IL-6) Aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
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spelling	oai:doaj.org-article:265c2b797bd046ebbc59e92a236554682021-11-28T12:30:35ZComparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults10.1186/s12868-021-00675-81471-2202https://doaj.org/article/265c2b797bd046ebbc59e92a236554682021-11-01T00:00:00Zhttps://doi.org/10.1186/s12868-021-00675-8https://doaj.org/toc/1471-2202Abstract Background Accumulating evidence shows that physical exercise has a positive effect on the release of neurotrophic factors and myokines. However, evidence regarding the optimal type of physical exercise for these release is still lacking. The aim of this study was to assess the acute and chronic effects of open-skill exercise (OSE) compared to closed-skill exercise (CSE) on serum and plasma levels of brain derived neurotrophic factor (BDNFS, BDNFP), and serum levels of insulin like growth factor 1 (IGF-1), and interleukin 6 (IL-6) in healthy older adults. Methods To investigate acute effects, thirty-eight participants were randomly assigned to either an intervention (badminton (aOSE) and bicycling (aCSE), n = 24, 65.83 ± 5.98 years) or control group (reading (CG), n = 14, 67.07 ± 2.37 years). Blood samples were taken immediately before and 5 min after each condition. During each condition, heart rate was monitored. The mean heart rate of aOSE and aCSE were equivalent (65 ± 5% of heart rate reserve). In a subsequent 12-week training-intervention, twenty-two participants were randomly assigned to either a sport-games (cOSE, n = 6, 64.50 ± 6.32) or a strength-endurance training (cCSE, n = 9, 64.89 ± 3.51) group to assess for chronic effects. Training intensity for both groups was adjusted to a subjective perceived exertion using the CR-10 scale (value 7). Blood samples were taken within one day after the training-intervention. Results BDNFS, BDNFP, IGF-1, and IL-6 levels increased after a single exercise session of 30 min. After 12 weeks of training BDNFS and IL-6 levels were elevated, whereas IGF-1 levels were reduced in both groups. However, only in the cOSE group these changes were significant. We could not find any significant differences between the exercise types. Conclusion Our results indicate that both exercise types are efficient to acutely increase BDNFS, BDNFP, IGF-1 and IL-6 serum levels in healthy older adults. Additionally, our results tend to support that OSE is more effective for improving basal BDNFS levels after 12 weeks of training.Tom BehrendtFranziska KirschnickLasse KrögerPhillip BeilekeMaxim RezepinTanja BrigadskiVolkmar LeßmannLutz SchegaBMCarticleOpen skill exerciseClosed skill exerciseBrain-derived neurotrophic factor (BDNF)Insulin-like growth factor 1 (IGF-1)Interleukin-6 (IL-6)AgingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurophysiology and neuropsychologyQP351-495ENBMC Neuroscience, Vol 22, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Open skill exercise Closed skill exercise Brain-derived neurotrophic factor (BDNF) Insulin-like growth factor 1 (IGF-1) Interleukin-6 (IL-6) Aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Open skill exercise Closed skill exercise Brain-derived neurotrophic factor (BDNF) Insulin-like growth factor 1 (IGF-1) Interleukin-6 (IL-6) Aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495 Tom Behrendt Franziska Kirschnick Lasse Kröger Phillip Beileke Maxim Rezepin Tanja Brigadski Volkmar Leßmann Lutz Schega Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults
description	Abstract Background Accumulating evidence shows that physical exercise has a positive effect on the release of neurotrophic factors and myokines. However, evidence regarding the optimal type of physical exercise for these release is still lacking. The aim of this study was to assess the acute and chronic effects of open-skill exercise (OSE) compared to closed-skill exercise (CSE) on serum and plasma levels of brain derived neurotrophic factor (BDNFS, BDNFP), and serum levels of insulin like growth factor 1 (IGF-1), and interleukin 6 (IL-6) in healthy older adults. Methods To investigate acute effects, thirty-eight participants were randomly assigned to either an intervention (badminton (aOSE) and bicycling (aCSE), n = 24, 65.83 ± 5.98 years) or control group (reading (CG), n = 14, 67.07 ± 2.37 years). Blood samples were taken immediately before and 5 min after each condition. During each condition, heart rate was monitored. The mean heart rate of aOSE and aCSE were equivalent (65 ± 5% of heart rate reserve). In a subsequent 12-week training-intervention, twenty-two participants were randomly assigned to either a sport-games (cOSE, n = 6, 64.50 ± 6.32) or a strength-endurance training (cCSE, n = 9, 64.89 ± 3.51) group to assess for chronic effects. Training intensity for both groups was adjusted to a subjective perceived exertion using the CR-10 scale (value 7). Blood samples were taken within one day after the training-intervention. Results BDNFS, BDNFP, IGF-1, and IL-6 levels increased after a single exercise session of 30 min. After 12 weeks of training BDNFS and IL-6 levels were elevated, whereas IGF-1 levels were reduced in both groups. However, only in the cOSE group these changes were significant. We could not find any significant differences between the exercise types. Conclusion Our results indicate that both exercise types are efficient to acutely increase BDNFS, BDNFP, IGF-1 and IL-6 serum levels in healthy older adults. Additionally, our results tend to support that OSE is more effective for improving basal BDNFS levels after 12 weeks of training.
format	article
author	Tom Behrendt Franziska Kirschnick Lasse Kröger Phillip Beileke Maxim Rezepin Tanja Brigadski Volkmar Leßmann Lutz Schega
author_facet	Tom Behrendt Franziska Kirschnick Lasse Kröger Phillip Beileke Maxim Rezepin Tanja Brigadski Volkmar Leßmann Lutz Schega
author_sort	Tom Behrendt
title	Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults
title_short	Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults
title_full	Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults
title_fullStr	Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults
title_full_unstemmed	Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults
title_sort	comparison of the effects of open vs. closed skill exercise on the acute and chronic bdnf, igf-1 and il-6 response in older healthy adults
publisher	BMC
publishDate	2021
url	https://doaj.org/article/265c2b797bd046ebbc59e92a23655468
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Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults

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