Ratios between circulating myeloid cells and lymphocytes are associated with mortality in severe COVID-19 patients

Recent studies indicate that host immune responses are dysregulated with either myeloid cell compartment or lymphocyte composition being disturbed in COVID-19. This study aimed to assess the impact of SARS-CoV-2 viral infection on the composition of circulating immune cells in severe COVID-19 patien...

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Autores principales:	Ma Hui, Lim Xiong Chang, Yu Qihong, Li Yi, Li Yuechuan, Jia Wei
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	covid-19 myeloid cells lymphocytes coagulation d-dimer Medicine R
Acceso en línea:	https://doaj.org/article/265e18707dfa45919c4b4be5ee28e61d
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spelling	oai:doaj.org-article:265e18707dfa45919c4b4be5ee28e61d2021-12-05T14:10:54ZRatios between circulating myeloid cells and lymphocytes are associated with mortality in severe COVID-19 patients2391-546310.1515/med-2021-0237https://doaj.org/article/265e18707dfa45919c4b4be5ee28e61d2021-02-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0237https://doaj.org/toc/2391-5463Recent studies indicate that host immune responses are dysregulated with either myeloid cell compartment or lymphocyte composition being disturbed in COVID-19. This study aimed to assess the impact of SARS-CoV-2 viral infection on the composition of circulating immune cells in severe COVID-19 patients. In this retrospective single-center cohort, 71 out of 87 COVID-19 patients admitted to the intense care unit for oxygen treatment were included in this study. Demographics, clinical features, comorbidities, and laboratory findings were collected on admission. Out of the 71 patients, 5 died from COVID-19. Compared with survived patients, deceased patients showed higher blood cell counts of neutrophils and monocytes but lower cell counts of lymphocytes. Intriguingly, the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and basophil-to-lymphocyte ratio (BLR) were markedly higher in deceased patients compared to survived patients. Furthermore, the lymphocyte counts were negatively correlated with D-dimer levels, while the ratios between myeloid cells and lymphocyte (NLR, MLR, and BLR) were positively correlated with D-dimer levels. Our findings revealed that the ratios between myeloid cells and lymphocytes were highly correlated with coagulation status and patient mortality in severe COVID-19.Ma HuiLim Xiong ChangYu QihongLi YiLi YuechuanJia WeiDe Gruyterarticlecovid-19myeloid cellslymphocytescoagulationd-dimerMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 351-360 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 myeloid cells lymphocytes coagulation d-dimer Medicine R
spellingShingle	covid-19 myeloid cells lymphocytes coagulation d-dimer Medicine R Ma Hui Lim Xiong Chang Yu Qihong Li Yi Li Yuechuan Jia Wei Ratios between circulating myeloid cells and lymphocytes are associated with mortality in severe COVID-19 patients
description	Recent studies indicate that host immune responses are dysregulated with either myeloid cell compartment or lymphocyte composition being disturbed in COVID-19. This study aimed to assess the impact of SARS-CoV-2 viral infection on the composition of circulating immune cells in severe COVID-19 patients. In this retrospective single-center cohort, 71 out of 87 COVID-19 patients admitted to the intense care unit for oxygen treatment were included in this study. Demographics, clinical features, comorbidities, and laboratory findings were collected on admission. Out of the 71 patients, 5 died from COVID-19. Compared with survived patients, deceased patients showed higher blood cell counts of neutrophils and monocytes but lower cell counts of lymphocytes. Intriguingly, the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and basophil-to-lymphocyte ratio (BLR) were markedly higher in deceased patients compared to survived patients. Furthermore, the lymphocyte counts were negatively correlated with D-dimer levels, while the ratios between myeloid cells and lymphocyte (NLR, MLR, and BLR) were positively correlated with D-dimer levels. Our findings revealed that the ratios between myeloid cells and lymphocytes were highly correlated with coagulation status and patient mortality in severe COVID-19.
format	article
author	Ma Hui Lim Xiong Chang Yu Qihong Li Yi Li Yuechuan Jia Wei
author_facet	Ma Hui Lim Xiong Chang Yu Qihong Li Yi Li Yuechuan Jia Wei
author_sort	Ma Hui
title	Ratios between circulating myeloid cells and lymphocytes are associated with mortality in severe COVID-19 patients
title_short	Ratios between circulating myeloid cells and lymphocytes are associated with mortality in severe COVID-19 patients
title_full	Ratios between circulating myeloid cells and lymphocytes are associated with mortality in severe COVID-19 patients
title_fullStr	Ratios between circulating myeloid cells and lymphocytes are associated with mortality in severe COVID-19 patients
title_full_unstemmed	Ratios between circulating myeloid cells and lymphocytes are associated with mortality in severe COVID-19 patients
title_sort	ratios between circulating myeloid cells and lymphocytes are associated with mortality in severe covid-19 patients
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/265e18707dfa45919c4b4be5ee28e61d
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Ratios between circulating myeloid cells and lymphocytes are associated with mortality in severe COVID-19 patients

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