Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice.

Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice.

Metformin is used as an anti-diabetic drug. Metformin ameliorates insulin resistance by improving insulin sensitivity in liver and skeletal muscle. Reduced mitochondrial content has been reported in type 2 diabetic muscles and it may contribute to decreased insulin sensitivity characteristic for dia...

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Main Authors: Jonas M Kristensen, Steen Larsen, Jørn W Helge, Flemming Dela, Jørgen F P Wojtaszewski
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/265ff3b51ed54a058260c1dd9026c6fd
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