PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological processes leading to cell death during v...

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Autores principales:	Natalya V. Maluchenko, Alexey V. Feofanov, Vasily M. Studitsky
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	PARP-1 polyphenols PARP-1 inhibitors Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/26611aef751b49b9ac76fbd4a016704f
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spelling	oai:doaj.org-article:26611aef751b49b9ac76fbd4a016704f2021-11-11T16:54:23ZPARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols10.3390/ijms2221114411422-00671661-6596https://doaj.org/article/26611aef751b49b9ac76fbd4a016704f2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11441https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological processes leading to cell death during various metabolic disorders, cardiovascular and neurodegenerative diseases. In contrast, tumor growth is accompanied by a moderate activation of PARP-1 that supports survival of tumor cells due to enhancement of DNA lesion repair and resistance to therapy by DNA damaging agents. That is why PARP inhibitors (PARPi) are promising agents for the therapy of tumor and metabolic diseases. A PARPi family is rapidly growing partly due to natural polyphenols discovered among plant secondary metabolites. This review describes mechanisms of PARP-1 participation in the development of various pathologies, analyzes multiple PARP-dependent pathways of cell degeneration and death, and discusses representative plant polyphenols, which can inhibit PARP-1 directly or suppress unwanted PARP-dependent cellular processes.Natalya V. MaluchenkoAlexey V. FeofanovVasily M. StuditskyMDPI AGarticlePARP-1polyphenolsPARP-1 inhibitorsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11441, p 11441 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PARP-1 polyphenols PARP-1 inhibitors Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	PARP-1 polyphenols PARP-1 inhibitors Biology (General) QH301-705.5 Chemistry QD1-999 Natalya V. Maluchenko Alexey V. Feofanov Vasily M. Studitsky PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
description	Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological processes leading to cell death during various metabolic disorders, cardiovascular and neurodegenerative diseases. In contrast, tumor growth is accompanied by a moderate activation of PARP-1 that supports survival of tumor cells due to enhancement of DNA lesion repair and resistance to therapy by DNA damaging agents. That is why PARP inhibitors (PARPi) are promising agents for the therapy of tumor and metabolic diseases. A PARPi family is rapidly growing partly due to natural polyphenols discovered among plant secondary metabolites. This review describes mechanisms of PARP-1 participation in the development of various pathologies, analyzes multiple PARP-dependent pathways of cell degeneration and death, and discusses representative plant polyphenols, which can inhibit PARP-1 directly or suppress unwanted PARP-dependent cellular processes.
format	article
author	Natalya V. Maluchenko Alexey V. Feofanov Vasily M. Studitsky
author_facet	Natalya V. Maluchenko Alexey V. Feofanov Vasily M. Studitsky
author_sort	Natalya V. Maluchenko
title	PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_short	PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_full	PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_fullStr	PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_full_unstemmed	PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_sort	parp-1-associated pathological processes: inhibition by natural polyphenols
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/26611aef751b49b9ac76fbd4a016704f
work_keys_str_mv	AT natalyavmaluchenko parp1associatedpathologicalprocessesinhibitionbynaturalpolyphenols AT alexeyvfeofanov parp1associatedpathologicalprocessesinhibitionbynaturalpolyphenols AT vasilymstuditsky parp1associatedpathologicalprocessesinhibitionbynaturalpolyphenols
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PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols

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