Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis.

Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis.

<h4>Background</h4>A variant of the CDKAL1 gene was reported to be associated with type 2 diabetes and reduced insulin release in humans; however, the role of CDKAL1 in β cells is largely unknown. Therefore, to determine the role of CDKAL1 in insulin release from β cells, we studied insu...

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Autores principales: Mica Ohara-Imaizumi, Masashi Yoshida, Kyota Aoyagi, Taro Saito, Tadashi Okamura, Hitoshi Takenaka, Yoshihiro Akimoto, Yoko Nakamichi, Rieko Takanashi-Yanobu, Chiyono Nishiwaki, Hayato Kawakami, Norihiro Kato, Shin-ichi Hisanaga, Masafumi Kakei, Shinya Nagamatsu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/26645a16c5be489a9a8fe1a5189a385b
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