Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data

Schizophrenia and rheumatoid arthritis: Exploring the link Researchers in the USA identify variations in eight genes that potentially confer differential risk for schizophrenia and rheumatoid arthritis. Previous studies have shown that patients with schizophrenia (and their relatives) have a reduced...

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Autores principales:	Tulsi A. Malavia, Srilakshmi Chaparala, Joel Wood, Kodavali Chowdari, Konasale M. Prasad, Lora McClain, Anil G. Jegga, Madhavi K. Ganapathiraju, Vishwajit L. Nimgaonkar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/2664fdd5354a4f128069c7d20bc58814
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spelling	oai:doaj.org-article:2664fdd5354a4f128069c7d20bc588142021-12-02T11:51:10ZGenerating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data10.1038/s41537-017-0010-z2334-265Xhttps://doaj.org/article/2664fdd5354a4f128069c7d20bc588142017-02-01T00:00:00Zhttps://doi.org/10.1038/s41537-017-0010-zhttps://doaj.org/toc/2334-265XSchizophrenia and rheumatoid arthritis: Exploring the link Researchers in the USA identify variations in eight genes that potentially confer differential risk for schizophrenia and rheumatoid arthritis. Previous studies have shown that patients with schizophrenia (and their relatives) have a reduced risk of developing rheumatoid arthritis and vice versa. Vishwajit Nimgaonkar, Madhavi Ganapathiraju and colleagues at the University of Pittsburgh compared single nucleotide variations in the genetic code that are significantly associated with these diseases. They found that the inverse risk between these disorders could be due to differences harbored in eight genes. Computational analyses of the protein interactomes of genes associated exclusively with rheumatoid arthritis and those with schizophrenia revealed common interacting partners that are known to be involved in immune and inflammatory responses, and shared disease pathways. Additional investigation of these proteins could shed further light on shared disease mechanisms.Tulsi A. MalaviaSrilakshmi ChaparalaJoel WoodKodavali ChowdariKonasale M. PrasadLora McClainAnil G. JeggaMadhavi K. GanapathirajuVishwajit L. NimgaonkarNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 3, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Tulsi A. Malavia Srilakshmi Chaparala Joel Wood Kodavali Chowdari Konasale M. Prasad Lora McClain Anil G. Jegga Madhavi K. Ganapathiraju Vishwajit L. Nimgaonkar Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data
description	Schizophrenia and rheumatoid arthritis: Exploring the link Researchers in the USA identify variations in eight genes that potentially confer differential risk for schizophrenia and rheumatoid arthritis. Previous studies have shown that patients with schizophrenia (and their relatives) have a reduced risk of developing rheumatoid arthritis and vice versa. Vishwajit Nimgaonkar, Madhavi Ganapathiraju and colleagues at the University of Pittsburgh compared single nucleotide variations in the genetic code that are significantly associated with these diseases. They found that the inverse risk between these disorders could be due to differences harbored in eight genes. Computational analyses of the protein interactomes of genes associated exclusively with rheumatoid arthritis and those with schizophrenia revealed common interacting partners that are known to be involved in immune and inflammatory responses, and shared disease pathways. Additional investigation of these proteins could shed further light on shared disease mechanisms.
format	article
author	Tulsi A. Malavia Srilakshmi Chaparala Joel Wood Kodavali Chowdari Konasale M. Prasad Lora McClain Anil G. Jegga Madhavi K. Ganapathiraju Vishwajit L. Nimgaonkar
author_facet	Tulsi A. Malavia Srilakshmi Chaparala Joel Wood Kodavali Chowdari Konasale M. Prasad Lora McClain Anil G. Jegga Madhavi K. Ganapathiraju Vishwajit L. Nimgaonkar
author_sort	Tulsi A. Malavia
title	Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data
title_short	Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data
title_full	Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data
title_fullStr	Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data
title_full_unstemmed	Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data
title_sort	generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2664fdd5354a4f128069c7d20bc58814
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Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data

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