GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection

GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection

GyrI-like proteins are small-molecule binding proteins that are widely distributed in prokaryotes and eukaryotes, with functions that are poorly characterized. Here, the authors identify GyrI-like proteins as cyclopropanoid cyclopropyl hydrolases that can confer resistance to cytotoxic cyclopropanoi...

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Autores principales: Hua Yuan, Jinru Zhang, Yujuan Cai, Sheng Wu, Kui Yang, H. C. Stephen Chan, Wei Huang, Wen-Bing Jin, Yan Li, Yue Yin, Yasuhiro Igarashi, Shuguang Yuan, Jiahai Zhou, Gong-Li Tang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/266a1355c538408382157a4388d51a1c
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spelling oai:doaj.org-article:266a1355c538408382157a4388d51a1c2021-12-02T14:40:48ZGyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection10.1038/s41467-017-01508-12041-1723https://doaj.org/article/266a1355c538408382157a4388d51a1c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01508-1https://doaj.org/toc/2041-1723GyrI-like proteins are small-molecule binding proteins that are widely distributed in prokaryotes and eukaryotes, with functions that are poorly characterized. Here, the authors identify GyrI-like proteins as cyclopropanoid cyclopropyl hydrolases that can confer resistance to cytotoxic cyclopropanoid compounds.Hua YuanJinru ZhangYujuan CaiSheng WuKui YangH. C. Stephen ChanWei HuangWen-Bing JinYan LiYue YinYasuhiro IgarashiShuguang YuanJiahai ZhouGong-Li TangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hua Yuan
Jinru Zhang
Yujuan Cai
Sheng Wu
Kui Yang
H. C. Stephen Chan
Wei Huang
Wen-Bing Jin
Yan Li
Yue Yin
Yasuhiro Igarashi
Shuguang Yuan
Jiahai Zhou
Gong-Li Tang
GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection
description GyrI-like proteins are small-molecule binding proteins that are widely distributed in prokaryotes and eukaryotes, with functions that are poorly characterized. Here, the authors identify GyrI-like proteins as cyclopropanoid cyclopropyl hydrolases that can confer resistance to cytotoxic cyclopropanoid compounds.
format article
author Hua Yuan
Jinru Zhang
Yujuan Cai
Sheng Wu
Kui Yang
H. C. Stephen Chan
Wei Huang
Wen-Bing Jin
Yan Li
Yue Yin
Yasuhiro Igarashi
Shuguang Yuan
Jiahai Zhou
Gong-Li Tang
author_facet Hua Yuan
Jinru Zhang
Yujuan Cai
Sheng Wu
Kui Yang
H. C. Stephen Chan
Wei Huang
Wen-Bing Jin
Yan Li
Yue Yin
Yasuhiro Igarashi
Shuguang Yuan
Jiahai Zhou
Gong-Li Tang
author_sort Hua Yuan
title GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection
title_short GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection
title_full GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection
title_fullStr GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection
title_full_unstemmed GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection
title_sort gyri-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/266a1355c538408382157a4388d51a1c
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AT jiahaizhou gyrilikeproteinscatalyzecyclopropanoidhydrolysistoconfercellularprotection
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