$Laser-induced corneal cross-linking upon photorefractive ablation with riboflavin$
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Laser-induced corneal cross-linking upon photorefractive ablation with riboflavin

Igor M Kornilovskiy,1 Elmar M Kasimov,2 Ayten I Sultanova,2 Alexander A Burtsev1 1Department of Eye Diseases, Federal State Budgetary Institution “National Pirogov Medical Surgical Centre”, Ministry of Health, Moscow, Russia; 2Department of Eye Diseases, Zarifa Aliyeva National...

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Autores principales:	Kornilovskiy IM, Kasimov EM, Sultanova AI, Burtsev AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	corneal cross-linking photorefractive ablation of cornea riboflavin. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/266a5b44ceec4dac812834003df31c5e
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spelling	oai:doaj.org-article:266a5b44ceec4dac812834003df31c5e2021-12-02T07:39:51ZLaser-induced corneal cross-linking upon photorefractive ablation with riboflavin1177-5483https://doaj.org/article/266a5b44ceec4dac812834003df31c5e2016-04-01T00:00:00Zhttps://www.dovepress.com/laser-induced-corneal-cross-linking-upon-photorefractive-ablation-with-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Igor M Kornilovskiy,1 Elmar M Kasimov,2 Ayten I Sultanova,2 Alexander A Burtsev1 1Department of Eye Diseases, Federal State Budgetary Institution “National Pirogov Medical Surgical Centre”, Ministry of Health, Moscow, Russia; 2Department of Eye Diseases, Zarifa Aliyeva National Ophthalmology Center, Ministry of Health, Baku, Azerbaijan Aim: To estimate the biomechanical effect of the laser-induced cross-linking resulting from photorefractive ablation of the cornea with riboflavin.Methods: Excimer laser ablation studies were performed ex vivo (32 eyes of 16 rabbits) by phototherapeutic keratectomy (PTK) and in vivo (24 eyes of 12 rabbits) by transepithelial photorefractive keratectomy (TransPRK), with and without riboflavin saturation of the stroma. Then, we performed corneal optical coherence tomography on 36 eyes of 18 patients with varying degrees of myopia at different times after the TransPRK was performed with riboflavin saturation of the stroma.Results: Biomechanical testing of corneal samples saturated with riboflavin revealed cross-linking effect accompanied by the increase in tensile strength and maximum strength. PTK showed increase in tensile strength from 5.1±1.4 to 7.2±1.6 MPa (P=0.001), while TransPRK showed increase in tensile strength from 8.8±0.9 to 12.8±1.3 MPa (P=0.0004). Maximum strength increased from 8.7±2.5 to 12.0±2.8 N (P=0.005) in PTK and from 12.8±1.6 to 18.3±1.2 N (P=0.0004) in TransPRK. Clinical optical coherence tomography studies of the biomicroscopic transparent cornea at different times after TransPRK showed increased density in the surface layers of the stroma and membrane-like structure beneath the epithelium.Conclusion: Photorefractive ablation of the preliminary corneal stroma saturation with riboflavin causes the effect of laser-induced cross-linking, which is attended with an increase in corneal tensile strength, maximum strength, increased density in the surface layers of the stroma, and formation of a membrane-like structure beneath the epithelium after TransPRK. Keywords: corneal cross-linking, photorefractive ablation of cornea, riboflavinKornilovskiy IMKasimov EMSultanova AIBurtsev AADove Medical Pressarticlecorneal cross-linkingphotorefractive ablation of corneariboflavin.OphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 587-592 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	corneal cross-linking photorefractive ablation of cornea riboflavin. Ophthalmology RE1-994
spellingShingle	corneal cross-linking photorefractive ablation of cornea riboflavin. Ophthalmology RE1-994 Kornilovskiy IM Kasimov EM Sultanova AI Burtsev AA Laser-induced corneal cross-linking upon photorefractive ablation with riboflavin
description	Igor M Kornilovskiy,1 Elmar M Kasimov,2 Ayten I Sultanova,2 Alexander A Burtsev1 1Department of Eye Diseases, Federal State Budgetary Institution “National Pirogov Medical Surgical Centre”, Ministry of Health, Moscow, Russia; 2Department of Eye Diseases, Zarifa Aliyeva National Ophthalmology Center, Ministry of Health, Baku, Azerbaijan Aim: To estimate the biomechanical effect of the laser-induced cross-linking resulting from photorefractive ablation of the cornea with riboflavin.Methods: Excimer laser ablation studies were performed ex vivo (32 eyes of 16 rabbits) by phototherapeutic keratectomy (PTK) and in vivo (24 eyes of 12 rabbits) by transepithelial photorefractive keratectomy (TransPRK), with and without riboflavin saturation of the stroma. Then, we performed corneal optical coherence tomography on 36 eyes of 18 patients with varying degrees of myopia at different times after the TransPRK was performed with riboflavin saturation of the stroma.Results: Biomechanical testing of corneal samples saturated with riboflavin revealed cross-linking effect accompanied by the increase in tensile strength and maximum strength. PTK showed increase in tensile strength from 5.1±1.4 to 7.2±1.6 MPa (P=0.001), while TransPRK showed increase in tensile strength from 8.8±0.9 to 12.8±1.3 MPa (P=0.0004). Maximum strength increased from 8.7±2.5 to 12.0±2.8 N (P=0.005) in PTK and from 12.8±1.6 to 18.3±1.2 N (P=0.0004) in TransPRK. Clinical optical coherence tomography studies of the biomicroscopic transparent cornea at different times after TransPRK showed increased density in the surface layers of the stroma and membrane-like structure beneath the epithelium.Conclusion: Photorefractive ablation of the preliminary corneal stroma saturation with riboflavin causes the effect of laser-induced cross-linking, which is attended with an increase in corneal tensile strength, maximum strength, increased density in the surface layers of the stroma, and formation of a membrane-like structure beneath the epithelium after TransPRK. Keywords: corneal cross-linking, photorefractive ablation of cornea, riboflavin
format	article
author	Kornilovskiy IM Kasimov EM Sultanova AI Burtsev AA
author_facet	Kornilovskiy IM Kasimov EM Sultanova AI Burtsev AA
author_sort	Kornilovskiy IM
title	Laser-induced corneal cross-linking upon photorefractive ablation with riboflavin
title_short	Laser-induced corneal cross-linking upon photorefractive ablation with riboflavin
title_full	Laser-induced corneal cross-linking upon photorefractive ablation with riboflavin
title_fullStr	Laser-induced corneal cross-linking upon photorefractive ablation with riboflavin
title_full_unstemmed	Laser-induced corneal cross-linking upon photorefractive ablation with riboflavin
title_sort	laser-induced corneal cross-linking upon photorefractive ablation with riboflavin
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/266a5b44ceec4dac812834003df31c5e
work_keys_str_mv	AT kornilovskiyim laserinducedcornealcrosslinkinguponphotorefractiveablationwithriboflavin AT kasimovem laserinducedcornealcrosslinkinguponphotorefractiveablationwithriboflavin AT sultanovaai laserinducedcornealcrosslinkinguponphotorefractiveablationwithriboflavin AT burtsevaa laserinducedcornealcrosslinkinguponphotorefractiveablationwithriboflavin
_version_	1718399270107742208

Laser-induced corneal cross-linking upon photorefractive ablation with riboflavin

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