ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

PIK3CA mutations and ARID1A loss co-exist in endometrial neoplasms. Here, the authors show that these co-mutations drive gene expression profiles correlated with differential chromatin accessibility and ARID1A binding in the endometrial epithelium, resulting in partial EMT and myometrial invasion.

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Autores principales:	Mike R. Wilson, Jake J. Reske, Jeanne Holladay, Genna E. Wilber, Mary Rhodes, Julie Koeman, Marie Adams, Ben Johnson, Ren-Wei Su, Niraj R. Joshi, Amanda L. Patterson, Hui Shen, Richard E. Leach, Jose M. Teixeira, Asgerally T. Fazleabas, Ronald L. Chandler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/266dcb657cd34fc29c11bd4ed2e4f504
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spelling	oai:doaj.org-article:266dcb657cd34fc29c11bd4ed2e4f5042021-12-02T14:38:46ZARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion10.1038/s41467-019-11403-62041-1723https://doaj.org/article/266dcb657cd34fc29c11bd4ed2e4f5042019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11403-6https://doaj.org/toc/2041-1723PIK3CA mutations and ARID1A loss co-exist in endometrial neoplasms. Here, the authors show that these co-mutations drive gene expression profiles correlated with differential chromatin accessibility and ARID1A binding in the endometrial epithelium, resulting in partial EMT and myometrial invasion.Mike R. WilsonJake J. ReskeJeanne HolladayGenna E. WilberMary RhodesJulie KoemanMarie AdamsBen JohnsonRen-Wei SuNiraj R. JoshiAmanda L. PattersonHui ShenRichard E. LeachJose M. TeixeiraAsgerally T. FazleabasRonald L. ChandlerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mike R. Wilson Jake J. Reske Jeanne Holladay Genna E. Wilber Mary Rhodes Julie Koeman Marie Adams Ben Johnson Ren-Wei Su Niraj R. Joshi Amanda L. Patterson Hui Shen Richard E. Leach Jose M. Teixeira Asgerally T. Fazleabas Ronald L. Chandler ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
description	PIK3CA mutations and ARID1A loss co-exist in endometrial neoplasms. Here, the authors show that these co-mutations drive gene expression profiles correlated with differential chromatin accessibility and ARID1A binding in the endometrial epithelium, resulting in partial EMT and myometrial invasion.
format	article
author	Mike R. Wilson Jake J. Reske Jeanne Holladay Genna E. Wilber Mary Rhodes Julie Koeman Marie Adams Ben Johnson Ren-Wei Su Niraj R. Joshi Amanda L. Patterson Hui Shen Richard E. Leach Jose M. Teixeira Asgerally T. Fazleabas Ronald L. Chandler
author_facet	Mike R. Wilson Jake J. Reske Jeanne Holladay Genna E. Wilber Mary Rhodes Julie Koeman Marie Adams Ben Johnson Ren-Wei Su Niraj R. Joshi Amanda L. Patterson Hui Shen Richard E. Leach Jose M. Teixeira Asgerally T. Fazleabas Ronald L. Chandler
author_sort	Mike R. Wilson
title	ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
title_short	ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
title_full	ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
title_fullStr	ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
title_full_unstemmed	ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
title_sort	arid1a and pi3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/266dcb657cd34fc29c11bd4ed2e4f504
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ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

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