Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment

Abstract Although long noncoding RNAs (lncRNAs) have been emerging as critical regulators in various tissues and biological processes, little is known about their expression and regulation during the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) in inflammatory microenvironm...

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Autores principales:	Qingbin Zhang, Li Chen, Shiman Cui, Yan Li, Qi Zhao, Wei Cao, Shixiang Lai, Sanjun Yin, Zhixiang Zuo, Jian Ren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2673cc6bd49442c98536aceda9b6160d
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spelling	oai:doaj.org-article:2673cc6bd49442c98536aceda9b6160d2021-12-02T15:04:51ZExpression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment10.1038/s41598-017-14451-42045-2322https://doaj.org/article/2673cc6bd49442c98536aceda9b6160d2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-14451-4https://doaj.org/toc/2045-2322Abstract Although long noncoding RNAs (lncRNAs) have been emerging as critical regulators in various tissues and biological processes, little is known about their expression and regulation during the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) in inflammatory microenvironment. In this study, we have identified 63 lncRNAs that are not annotated in previous database. These novel lncRNAs were not randomly located in the genome but preferentially located near protein-coding genes related to particular functions and diseases, such as stem cell maintenance and differentiation, development disorders and inflammatory diseases. Moreover, we have identified 650 differentially expressed lncRNAs among different subsets of PDLSCs. Pathway enrichment analysis for neighboring protein-coding genes of these differentially expressed lncRNAs revealed stem cell differentiation related functions. Many of these differentially expressed lncRNAs function as competing endogenous RNAs that regulate protein-coding transcripts through competing shared miRNAs.Qingbin ZhangLi ChenShiman CuiYan LiQi ZhaoWei CaoShixiang LaiSanjun YinZhixiang ZuoJian RenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qingbin Zhang Li Chen Shiman Cui Yan Li Qi Zhao Wei Cao Shixiang Lai Sanjun Yin Zhixiang Zuo Jian Ren Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment
description	Abstract Although long noncoding RNAs (lncRNAs) have been emerging as critical regulators in various tissues and biological processes, little is known about their expression and regulation during the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) in inflammatory microenvironment. In this study, we have identified 63 lncRNAs that are not annotated in previous database. These novel lncRNAs were not randomly located in the genome but preferentially located near protein-coding genes related to particular functions and diseases, such as stem cell maintenance and differentiation, development disorders and inflammatory diseases. Moreover, we have identified 650 differentially expressed lncRNAs among different subsets of PDLSCs. Pathway enrichment analysis for neighboring protein-coding genes of these differentially expressed lncRNAs revealed stem cell differentiation related functions. Many of these differentially expressed lncRNAs function as competing endogenous RNAs that regulate protein-coding transcripts through competing shared miRNAs.
format	article
author	Qingbin Zhang Li Chen Shiman Cui Yan Li Qi Zhao Wei Cao Shixiang Lai Sanjun Yin Zhixiang Zuo Jian Ren
author_facet	Qingbin Zhang Li Chen Shiman Cui Yan Li Qi Zhao Wei Cao Shixiang Lai Sanjun Yin Zhixiang Zuo Jian Ren
author_sort	Qingbin Zhang
title	Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment
title_short	Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment
title_full	Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment
title_fullStr	Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment
title_full_unstemmed	Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment
title_sort	expression and regulation of long noncoding rnas during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2673cc6bd49442c98536aceda9b6160d
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Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment

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