Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.

<h4>Background</h4>MRI-based diffusion-weighted imaging (DWI) visualizes the local differences in water diffusion in vivo. The prognostic value of DWI signal intensities on the source images and apparent diffusion coefficient (ADC) maps respectively has not yet been studied in brain meta...

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Autores principales:	Anna Sophie Berghoff, Thomas Spanberger, Aysegül Ilhan-Mutlu, Manuel Magerle, Markus Hutterer, Adelheid Woehrer, Monika Hackl, Georg Widhalm, Karin Dieckmann, Christine Marosi, Peter Birner, Daniela Prayer, Matthias Preusser
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/26763be01b874b12a440e5920935294e
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spelling	oai:doaj.org-article:26763be01b874b12a440e5920935294e2021-11-18T07:58:48ZPreoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.1932-620310.1371/journal.pone.0055464https://doaj.org/article/26763be01b874b12a440e5920935294e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23393579/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>MRI-based diffusion-weighted imaging (DWI) visualizes the local differences in water diffusion in vivo. The prognostic value of DWI signal intensities on the source images and apparent diffusion coefficient (ADC) maps respectively has not yet been studied in brain metastases (BM).<h4>Methods</h4>We included into this retrospective analysis all patients operated for single BM at our institution between 2002 and 2010, in whom presurgical DWI and BM tissue samples were available. We recorded relevant clinical data, assessed DWI signal intensity and apparent diffusion coefficient (ADC) values and performed histopathological analysis of BM tissues. Statistical analyses including uni- and multivariate survival analyses were performed.<h4>Results</h4>65 patients (34 female, 31 male) with a median overall survival time (OS) of 15 months (range 0-99 months) were available for this study. 19 (29.2%) patients presented with hyper-, 3 (4.6%) with iso-, and 43 (66.2%) with hypointense DWI. ADCmean values could be determined in 32 (49.2%) patients, ranged from 456.4 to 1691.8*10⁻⁶ mm²/s (median 969.5) and showed a highly significant correlation with DWI signal intensity. DWI hyperintensity correlated significantly with high amount of interstitial reticulin deposition. In univariate analysis, patients with hyperintense DWI (5 months) and low ADCmean values (7 months) had significantly worse OS than patients with iso/hypointense DWI (16 months) and high ADCmean values (30 months), respectively. In multivariate survival analysis, high ADCmean values retained independent statistical significance.<h4>Conclusions</h4>Preoperative DWI findings strongly and independently correlate with OS in patients operated for single BM and are related to interstitial fibrosis. Inclusion of DWI parameters into established risk stratification scores for BM patients should be considered.Anna Sophie BerghoffThomas SpanbergerAysegül Ilhan-MutluManuel MagerleMarkus HuttererAdelheid WoehrerMonika HacklGeorg WidhalmKarin DieckmannChristine MarosiPeter BirnerDaniela PrayerMatthias PreusserPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55464 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Sophie Berghoff Thomas Spanberger Aysegül Ilhan-Mutlu Manuel Magerle Markus Hutterer Adelheid Woehrer Monika Hackl Georg Widhalm Karin Dieckmann Christine Marosi Peter Birner Daniela Prayer Matthias Preusser Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.
description	<h4>Background</h4>MRI-based diffusion-weighted imaging (DWI) visualizes the local differences in water diffusion in vivo. The prognostic value of DWI signal intensities on the source images and apparent diffusion coefficient (ADC) maps respectively has not yet been studied in brain metastases (BM).<h4>Methods</h4>We included into this retrospective analysis all patients operated for single BM at our institution between 2002 and 2010, in whom presurgical DWI and BM tissue samples were available. We recorded relevant clinical data, assessed DWI signal intensity and apparent diffusion coefficient (ADC) values and performed histopathological analysis of BM tissues. Statistical analyses including uni- and multivariate survival analyses were performed.<h4>Results</h4>65 patients (34 female, 31 male) with a median overall survival time (OS) of 15 months (range 0-99 months) were available for this study. 19 (29.2%) patients presented with hyper-, 3 (4.6%) with iso-, and 43 (66.2%) with hypointense DWI. ADCmean values could be determined in 32 (49.2%) patients, ranged from 456.4 to 1691.8*10⁻⁶ mm²/s (median 969.5) and showed a highly significant correlation with DWI signal intensity. DWI hyperintensity correlated significantly with high amount of interstitial reticulin deposition. In univariate analysis, patients with hyperintense DWI (5 months) and low ADCmean values (7 months) had significantly worse OS than patients with iso/hypointense DWI (16 months) and high ADCmean values (30 months), respectively. In multivariate survival analysis, high ADCmean values retained independent statistical significance.<h4>Conclusions</h4>Preoperative DWI findings strongly and independently correlate with OS in patients operated for single BM and are related to interstitial fibrosis. Inclusion of DWI parameters into established risk stratification scores for BM patients should be considered.
format	article
author	Anna Sophie Berghoff Thomas Spanberger Aysegül Ilhan-Mutlu Manuel Magerle Markus Hutterer Adelheid Woehrer Monika Hackl Georg Widhalm Karin Dieckmann Christine Marosi Peter Birner Daniela Prayer Matthias Preusser
author_facet	Anna Sophie Berghoff Thomas Spanberger Aysegül Ilhan-Mutlu Manuel Magerle Markus Hutterer Adelheid Woehrer Monika Hackl Georg Widhalm Karin Dieckmann Christine Marosi Peter Birner Daniela Prayer Matthias Preusser
author_sort	Anna Sophie Berghoff
title	Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.
title_short	Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.
title_full	Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.
title_fullStr	Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.
title_full_unstemmed	Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.
title_sort	preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/26763be01b874b12a440e5920935294e
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Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times.

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