Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation

Mohammadi et al. show that the transplantation of pancreatic islets within mesenchymal-stem cell (MSC) exosome-loaded hybrid alginate microcapsules in diabetic mice lead to diminished immune-based foreign body response and hyperglycemia control. This is due to immunomodulatory behavior of MSC exosom...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M. Rezaa Mohammadi, Samuel Mathew Rodriguez, Jennifer Cam Luong, Shiri Li, Rui Cao, Hamad Alshetaiwi, Hien Lau, Hayk Davtyan, Mathew Blurton Jones, Mahtab Jafari, Kai Kessenbrock, S. Armando Villalta, Paul de Vos, Weian Zhao, Jonathan R. T. Lakey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2679dce50030425f97c4feb28fe920b9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2679dce50030425f97c4feb28fe920b9
record_format	dspace
spelling	oai:doaj.org-article:2679dce50030425f97c4feb28fe920b92021-12-02T15:56:40ZExosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation10.1038/s42003-021-02229-42399-3642https://doaj.org/article/2679dce50030425f97c4feb28fe920b92021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02229-4https://doaj.org/toc/2399-3642Mohammadi et al. show that the transplantation of pancreatic islets within mesenchymal-stem cell (MSC) exosome-loaded hybrid alginate microcapsules in diabetic mice lead to diminished immune-based foreign body response and hyperglycemia control. This is due to immunomodulatory behavior of MSC exosomes at the engraftment site where they exert local immunosuppressive effects.M. Rezaa MohammadiSamuel Mathew RodriguezJennifer Cam LuongShiri LiRui CaoHamad AlshetaiwiHien LauHayk DavtyanMathew Blurton JonesMahtab JafariKai KessenbrockS. Armando VillaltaPaul de VosWeian ZhaoJonathan R. T. LakeyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 M. Rezaa Mohammadi Samuel Mathew Rodriguez Jennifer Cam Luong Shiri Li Rui Cao Hamad Alshetaiwi Hien Lau Hayk Davtyan Mathew Blurton Jones Mahtab Jafari Kai Kessenbrock S. Armando Villalta Paul de Vos Weian Zhao Jonathan R. T. Lakey Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation
description	Mohammadi et al. show that the transplantation of pancreatic islets within mesenchymal-stem cell (MSC) exosome-loaded hybrid alginate microcapsules in diabetic mice lead to diminished immune-based foreign body response and hyperglycemia control. This is due to immunomodulatory behavior of MSC exosomes at the engraftment site where they exert local immunosuppressive effects.
format	article
author	M. Rezaa Mohammadi Samuel Mathew Rodriguez Jennifer Cam Luong Shiri Li Rui Cao Hamad Alshetaiwi Hien Lau Hayk Davtyan Mathew Blurton Jones Mahtab Jafari Kai Kessenbrock S. Armando Villalta Paul de Vos Weian Zhao Jonathan R. T. Lakey
author_facet	M. Rezaa Mohammadi Samuel Mathew Rodriguez Jennifer Cam Luong Shiri Li Rui Cao Hamad Alshetaiwi Hien Lau Hayk Davtyan Mathew Blurton Jones Mahtab Jafari Kai Kessenbrock S. Armando Villalta Paul de Vos Weian Zhao Jonathan R. T. Lakey
author_sort	M. Rezaa Mohammadi
title	Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation
title_short	Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation
title_full	Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation
title_fullStr	Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation
title_full_unstemmed	Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation
title_sort	exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2679dce50030425f97c4feb28fe920b9
work_keys_str_mv	AT mrezaamohammadi exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT samuelmathewrodriguez exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT jennifercamluong exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT shirili exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT ruicao exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT hamadalshetaiwi exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT hienlau exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT haykdavtyan exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT mathewblurtonjones exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT mahtabjafari exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT kaikessenbrock exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT sarmandovillalta exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT pauldevos exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT weianzhao exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation AT jonathanrtlakey exosomeloadedimmunomodulatorybiomaterialsalleviatelocalimmuneresponseinimmunocompetentdiabeticmicepostisletxenotransplantation
_version_	1718385380356521984

Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation

Ejemplares similares