Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation

Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation

Mohammadi et al. show that the transplantation of pancreatic islets within mesenchymal-stem cell (MSC) exosome-loaded hybrid alginate microcapsules in diabetic mice lead to diminished immune-based foreign body response and hyperglycemia control. This is due to immunomodulatory behavior of MSC exosom...

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Bibliographic Details
Main Authors: M. Rezaa Mohammadi, Samuel Mathew Rodriguez, Jennifer Cam Luong, Shiri Li, Rui Cao, Hamad Alshetaiwi, Hien Lau, Hayk Davtyan, Mathew Blurton Jones, Mahtab Jafari, Kai Kessenbrock, S. Armando Villalta, Paul de Vos, Weian Zhao, Jonathan R. T. Lakey
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/2679dce50030425f97c4feb28fe920b9
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https://doaj.org/article/2679dce50030425f97c4feb28fe920b9

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